CD122-selective IL-2/anti-IL-2 complexes reduce regulatory T cell function and promote CD8+ T cell polyfunctionality for durable ovarian cancer immunotherapy

被引:0
|
作者
Drerup, Justin M.
Pandeswara, Sri Lakshmi
Liu, Aijie
Clark, Curtis A.
Padron, Alvaro S.
Chen, Wanjiao
Hurez, Vincent
Curiel, Tyler J.
机构
关键词
D O I
10.1158/1538-7445.AM2017-1608
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1608
引用
收藏
页数:2
相关论文
共 50 条
  • [1] CD122-SELECTIVE IL-2 COMPLEXES TREAT OVARIAN CARCINOMAS, INDUCE TREG FRAGILITY AND PROMOTE T CELL STEM CELLS
    Deng, Yilun
    Drerup, Justin
    Zhang, Xinyue
    Reyes, Ryan
    Mendez, Jenny
    Kancharla, Aravind
    Garcia, Myrna
    Bai, Haiyan
    Padron, Alvaro
    Gupta, Harshita
    Curiel, Tyler
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A414 - A415
  • [2] CD122-SELECTIVE IL-2 COMPLEXES TREAT OVARIAN CARCINOMAS, INDUCE TREG FRAGILITY AND PROMOTE T CELL STEM CELLS
    Deng, Yilun
    Drerup, Justin Michael
    Zhang, Xinyue
    Reyes, Ryan M.
    Mendez, Jenny
    Raeber, Miro E.
    Garcia, Myrna G.
    Pardon, Alvaro S.
    Gupta, Harshita B.
    Boyman, Onur
    Curiel, Tyler J.
    [J]. JOURNAL OF IMMUNOLOGY, 2021, 206
  • [3] ANV419 IS A NOVEL CD122-SELECTIVE IL-2/ANTI-IL-2 ANTIBODY FUSION PROTEIN WITH POTENT CD8 T CELL AND NK CELL STIMULATORY FUNCTION IN VITRO AND IN VIVO
    Huber, Christoph
    Katopodis, Andreas
    Branetti, Barbara
    Rondeau, Jean-Michel
    Popp, Simone
    Regnier, Catherine
    Kaiser, Daniel
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A343 - A343
  • [4] IL-2 complex rescues CD8+ T cell tolerance for cancer immunotherapy
    Swier, Lauryn
    Berrien, Melissa
    Teague, Ryan
    [J]. JOURNAL OF IMMUNOLOGY, 2015, 194
  • [5] CD122-selective IL-2/anti-IL-2 mAb complex enhances the function of innate and adaptive immunity against cancers
    Shimizu, Kanako
    Ueda, Shogo
    Fujii, Shinichiro
    [J]. CANCER SCIENCE, 2023, 114 : 1193 - 1193
  • [6] IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells
    Mostboeck, Sven
    Lutsiak, M. E. Christine
    Milenic, Diane E.
    Baidoo, Kwamena
    Schlom, Jeffrey
    Sabzevari, Helen
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 180 (07): : 5118 - 5129
  • [7] CD122-selective IL-2 complexes treat ovarian carcinomas, possibly by dysregulating Treg differentiation and reducing suppression, and promoting T cell stem cells
    Deng, Yilun
    Drerup, Justin
    Zhang, Xinyue
    Reyes, Ryan
    Mendez, Jenny
    Garcia, Myrna
    Padron, Alvaro
    Gupta, Harshita
    Curiel, Tyler
    [J]. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
  • [8] In Vivo Expansion of Activated Naive CD8+ T Cells and NK Cells Driven by Complexes of IL-2 and Anti-IL-2 Monoclonal Antibody As Novel Approach of Cancer Immunotherapy
    Tomala, Jakub
    Chmelova, Helena
    Mrkvan, Tomas
    Rihova, Blanka
    Kovar, Marek
    [J]. JOURNAL OF IMMUNOLOGY, 2009, 183 (08): : 4904 - 4912
  • [9] Unique Features of Naive CD8+ T Cell Activation by IL-2
    Cho, Jae-Ho
    Kim, Hee-Ok
    Kim, Kyu-Sik
    Yang, Deok-Hwan
    Surh, Charles D.
    Sprent, Jonathan
    [J]. JOURNAL OF IMMUNOLOGY, 2013, 191 (11): : 5559 - 5573
  • [10] IL-2/anti-IL-2 complexes ameliorate lupus nephritis by expansion of CD4+CD25+Foxp3+ regulatory T cells
    Yan, Ji-Jing
    Lee, Jae-Ghi
    Jang, Joon Young
    Koo, Tai Yeon
    Ahn, Curie
    Yang, Jaeseok
    [J]. KIDNEY INTERNATIONAL, 2017, 91 (03) : 603 - 615