Recombinant bacillus Calmette-Guerin in urothelial bladder cancer immunotherapy: current strategies

被引：8
|
作者：
Wang, Yonghua [1 ]
Yang, Meng [1 ]
Yu, Qinchao [1 ]
Yu, Lun [1 ]
Shao, Shixiu [1 ]
Wang, Xinsheng [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Urol, Qingdao 266071, Peoples R China
来源：
EXPERT REVIEW OF ANTICANCER THERAPY | 2015年 / 15卷 / 01期
基金：
中国国家自然科学基金;
关键词：
bacillus Calmette-Guerin; BCG; immunotherapy; intravesical therapy; recombinant BCG; urothelial bladder cancer; TRANSITIONAL-CELL CARCINOMA; EXPRESSING PERTUSSIS TOXIN; GAMMA-INDUCING FACTOR; MYCOBACTERIUM-BOVIS; IFN-GAMMA; INTRAVESICAL THERAPY; DNA VACCINES; MITOMYCIN-C; TH1-STIMULATING CYTOKINES; PLUS INTERFERON-ALPHA-2B;
D O I：
10.1586/14737140.2015.961430
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bacillus Calmette-Guerin (BCG) has been used in the intravesical treatment of urothelial bladder cancer (UBC) for three decades. Despite its efficacy, intravesical BCG therapy is associated with some limitations such as side effects and BCG failure, which have inspired multiple ways to improve it. Recent advances have focused on recombinant BCG (rBCG) which provides a novel tactic for modification of BCG. To date, a number of rBCG strains have been developed and demonstrated to encourage efficacy and safety in preclinical and clinical studies. This review summarizes current rBCG strategies, concerns and future directions in UBC immunotherapy with an intention to encourage further research and eventually to inform clinical decisions.
引用
收藏
页码：85 / 93
页数：9
相关论文
共 50 条
  • [1] Bacillus Calmette-Guerin immunotherapy for urothelial carcinoma of the bladder
    Kresowik, Timothy P.
    Griffith, Thomas S.
    [J]. IMMUNOTHERAPY, 2009, 1 (02) : 281 - 288
  • [2] BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY IN BLADDER-CANCER
    不详
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (09): : 1238 - 1240
  • [3] BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY FOR BLADDER-CANCER
    LAMM, DL
    [J]. JOURNAL OF UROLOGY, 1985, 134 (01): : 40 - 47
  • [4] Applications of bacillus Calmette-Guerin and recombinant bacillus Calmette-Guerin in vaccine development and tumor immunotherapy
    Zheng, Yuan-qiang
    Naguib, Youssef W.
    Dong, Yixuan
    Shi, Yan-chun
    Bou, Shorgan
    Cui, Zhengrong
    [J]. EXPERT REVIEW OF VACCINES, 2015, 14 (09) : 1255 - 1275
  • [5] Recent advances in bacillus Calmette-Guerin immunotherapy in bladder cancer
    Alexandroff, Anton B.
    Nicholson, Steve
    Patel, Poulam M.
    Jackson, Andrew M.
    [J]. IMMUNOTHERAPY, 2010, 2 (04) : 551 - 560
  • [6] BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY OF SUPERFICIAL BLADDER-CANCER
    LAMM, DL
    THOR, DE
    HARRIS, SC
    REYNA, JA
    STOGDILL, VD
    RADWIN, HM
    [J]. JOURNAL OF UROLOGY, 1980, 124 (01): : 38 - 42
  • [7] BACILLUS CALMETTE-GUERIN IMMUNOTHERAPY OF INFILTRATING BLADDER-CANCER
    NETTO, NR
    LEMOS, GC
    [J]. JOURNAL OF UROLOGY, 1984, 132 (04): : 675 - 677
  • [8] Bacillus Calmette-Guerin Immunotherapy for Cancer
    Cardillo, Fabiola
    Bonfim, Maiara
    da Silva Vasconcelos Sousa, Periela
    Mengel, Jose
    Ribeiro Castello-Branco, Luiz Roberto
    Pinho, Rosa Teixeira
    [J]. VACCINES, 2021, 9 (05)
  • [9] Intravesical instillation therapy with bacillus Calmette-Guerin for superficial bladder cancer: Study of the mechanism of bacillus Calmette-Guerin immunotherapy
    Shintani, Yasuyo
    Sawada, Yoshihisa
    Inagaki, Takeshi
    Kohjimoto, Yasuo
    Uekado, Yasunari
    Shinka, Toshiaki
    [J]. INTERNATIONAL JOURNAL OF UROLOGY, 2007, 14 (02) : 140 - 146
  • [10] Bacillus Calmette-Guerin and bladder cancer
    Razack, Azad H. A.
    [J]. ASIAN JOURNAL OF SURGERY, 2007, 30 (04) : 302 - 309
12345