Genotoxic effect of vanillin derivatives

被引:0
|
作者
Mikulásová, M [1 ]
Bohovicová, I [1 ]
机构
[1] Slovak Univ Technol Bratislava, Fac Chem Technol, Dept Biochem & Microbiol, SK-81237 Bratislava, Slovakia
来源
BIOLOGIA | 2000年 / 55卷 / 03期
关键词
vanillin; genotoxicity; mutagenicity; DNA-repair test;
D O I
暂无
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A liquid micromodification of the DNA-repair test with the wild repair proficient and three repair-deficient strains of Escherichia coli was used for determination of the genotoxic effect of 4-hydroxy-3-methoxybenzaldehyde (vanillin) and other phenolic compounds. The negative results obtained were confirmed by the assessment of the number of revertants via the Ames test. The ability of 4-hydroxy-3-methoxybenzaldehyde (vanillin) and 2-hydroxy-3-methoxybenzaldehyde (o-vanillin) to increase the viability of cells and to decrease the number of mutations in bacteria pre-treated with 4-nitrochinolin-1-oxide was verified.
引用
收藏
页码:229 / 234
页数:6
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