Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?

被引：67
|
作者：
Johannson, Kerri A. [1 ]
Strambu, Irina [2 ]
Ravaglia, Claudia [3 ]
Grutters, Jan C. [4 ,5 ]
Valenzuela, Claudia [6 ]
Mogulkoc, Nesrin [7 ]
Luppi, Fabrizio [8 ]
Richeldi, Luca [9 ]
Wells, Athol U. [10 ]
Vancheri, Carlo [11 ]
Kreuter, Michael [12 ,13 ]
机构：
[1] Univ Calgary, Dept Med, Calgary, AB, Canada
[2] Univ Med & Pharm Carol Davila, Pulmonol Dept, Bucharest, Romania
[3] GB Morgagni L Pierantoni Hosp, Dept Thorac Dis, Pulmonol Unit, Forli, Italy
[4] St Antonius Hosp, Dept Pulmonol, Interstitial Lung Dis Ctr Excellence, Nieuwegein, Netherlands
[5] Univ Med Ctr Utrecht, Div Heart & Lungs, Utrecht, Netherlands
[6] Hosp Univ Princesa, Pulmonol Dept, Madrid, Spain
[7] Univ Ege, Pulmonol Dept, Bornova, Turkey
[8] Univ Hosp Modena, Ctr Rare Lung Dis, Modena, Italy
[9] Univ Cattolica Sacro Cuore, UOC Pneumol, Rome, Italy
[10] Royal Brompton Hosp, Interstitial Lung Dis Unit, London SW3 6NP, England
[11] Univ Catania, Dept Clin & Expt Med, Reg Referral Ctr Rare Lung Dis, Catania, Sicily, Italy
[12] Heidelberg Univ, Thoraxklin, Ctr Interstitial & Rare Lung Dis, Pneumol & Resp Crit Care Med, Heidelberg, Germany
[13] German Ctr Lung Res, Translat Lung Res Ctr Heidelberg, Heidelberg, Germany
来源：
LANCET RESPIRATORY MEDICINE | 2017年 / 5卷 / 07期
关键词：
GASTROESOPHAGEAL-REFLUX DISEASE; PROTON PUMP INHIBITORS; CHRONIC ASPIRATION; CLINICAL-PRACTICE; HIATAL-HERNIA; LUNG-DISEASE; MANAGEMENT; PREVALENCE; RISK; PROGRESSION;
D O I：
10.1016/S2213-2600(17)30219-9
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of complex cause. Gastro-oesophageal reflux (GER) and microaspiration have been proposed as risk factors for the development and progression of IPF, but robust definitive data are few. A recent international guideline conditionally recommended the use of antacid therapy (proton pump inhibitors or histamine-2-receptor antagonists) for patients with IPF, in the absence of oesophageal reflux or symptoms. In this Position Paper, we summarise the literature addressing the association between GER and IPF, and also identify future research priorities that could clarify this issue. We shed light on the process through which the guideline recommendation was achieved and aim to contextualise the recommendation for providers caring for patients with IPF.
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页码：591 / 598
页数：8
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