Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study

被引：43
|
作者：
Pan, WH [1 ]
Chen, JW
Fann, C
Jou, YS
Wu, SY
机构：
[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Cardiol, Taipei, Taiwan
[3] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 112, Taiwan
[4] Natl Hlth Res Inst, Div Mol & Genomic Med, Taipei, Taiwan
[5] Natl Def Med Ctr, Inst Life Sci, Taipei, Taiwan
来源：
HUMAN GENETICS | 2000年 / 107卷 / 03期
关键词：
D O I：
10.1007/s004390000365
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S 1145 (P=0.0284), and D17S2193 (P=0.0256), which were located ;near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S 1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.
引用
收藏
页码：210 / 215
页数：6
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