Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study

被引:43
|
作者
Pan, WH [1 ]
Chen, JW
Fann, C
Jou, YS
Wu, SY
机构
[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
[2] Taipei Vet Gen Hosp, Dept Cardiol, Taipei, Taiwan
[3] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 112, Taiwan
[4] Natl Hlth Res Inst, Div Mol & Genomic Med, Taipei, Taiwan
[5] Natl Def Med Ctr, Inst Life Sci, Taipei, Taiwan
关键词
D O I
10.1007/s004390000365
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A genetic linkage study of young-onset hypertension was performed on data from 59 nucleus families of Han Chinese residing in Taiwan. Thirty seven microsatellite markers near 18 hypertension candidate genes were genotyped. In a nonparametric identity-by-descent sibpair analysis, a positive linkage signal (defined as P<0.05) was found for four microsatellite markers, viz., D1S1612 (P=0.0162), D1S547 (P=0.0263), D8S 1145 (P=0.0284), and D17S2193 (P=0.0256), which were located ;near genes for atrial natriuretic peptide (NPPA)/glucose transporter 5 (SLC2A5), angiotensinogen (AGT), lipoprotein lipase (LPL), and angiotensin-conveting enzyme (DCP1), respectively. Marker D5S 1480 located near beta-2-adrenergic receptor (ADRB2) had a borderline P value (P=0.0785) for the positive signal. Comprehensive genotyping with further markers in these regions is underway to confirm whether these genes are linked to young-onset hypertension.
引用
收藏
页码:210 / 215
页数:6
相关论文
共 50 条
  • [1] Linkage analysis with candidate genes: the Taiwan young-onset hypertension genetic study
    Wen-Harn Pan
    Jaw-Wen Chen
    Cathy Fann
    Yuh-Shan Jou
    Sheng-Yeu Wu
    [J]. Human Genetics, 2000, 107 : 210 - 215
  • [2] Lipoprotein lipase gene is linked and associated with hypertension in Taiwan young-onset hypertension genetic study
    Chen, P
    Jou, YS
    Fann, CSJ
    Chen, JW
    Wu, SY
    Pan, WH
    [J]. JOURNAL OF BIOMEDICAL SCIENCE, 2005, 12 (04) : 651 - 658
  • [3] Studies of candidate genes on young-onset parkinsonian in Russian population
    Illarioshkin, SN
    Bagieva, GKH
    Slominsky, PA
    Klyushnikov, SA
    Shadrina, MI
    Markova, ED
    Zagorovskaya, TB
    Limborska, SA
    Ivanova-Smolenskaya, IA
    [J]. NEUROLOGY, 2006, 66 (05) : A144 - A144
  • [4] Genetic study of young-onset dementia using targeted gene panel sequencing in Taiwan
    Hsu, Jung-Lung
    Lin, Chin-Hsien
    Chen, Pei-Lung
    Lin, Kun-Ju
    Chen, Ta-Fu
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2021, 186 (02) : 67 - 76
  • [5] Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan
    Yang, Hsin-Chou
    Liang, Yu-Jen
    Wu, Yi-Lin
    Chung, Chia-Min
    Chiang, Kuang-Mao
    Ho, Hung-Yun
    Ting, Chih-Tai
    Lin, Tsung-Hsien
    Sheu, Sheng-Hsiung
    Tsai, Wei-Chuan
    Chen, Jyh-Hong
    Leu, Hsin-Bang
    Yin, Wei-Hsian
    Chiu, Ting-Yu
    Chen, Chin-Iuan
    Fann, Cathy S. J.
    Wu, Jer-Yuarn
    Lin, Teng-Nan
    Lin, Shing-Jong
    Chen, Yuan-Tsong
    Chen, Jaw-Wen
    Pan, Wen-Harn
    [J]. PLOS ONE, 2009, 4 (05):
  • [6] Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study
    Wang, Ruey-Yun
    Chung, Chia-Min
    Fann, Cathy S. J.
    Yang, Hsin-Chou
    Chen, Jaw-Wen
    Jong, Yuh-Shiun
    Jou, Yuh-Shan
    Lo, Huey-Ming
    Ho, Feng-Ming
    Kang, Chih-Sen
    Chen, Chien-Chung
    Chang, Huan-Cheng
    Shyue, Song-Kun
    Pan, Wen-Harn
    [J]. HUMAN HEREDITY, 2008, 65 (02) : 85 - 90
  • [7] Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
    Hsin-Bang Leu
    Chia-Min Chung
    Shing-Jong Lin
    Kuang-Mao Chiang
    Hsin-Chou Yang
    Hung-Yun Ho
    Chih-Tai Ting
    Tsung-Hsien Lin
    Sheng-Hsiung Sheu
    Wei-Chuan Tsai
    Jyh-Hong Chen
    Wei-Hsian Yin
    Ting-Yu Chiu
    Chin-Iuan Chen
    Cathy SJ Fann
    Yuan-Tsong Chen
    Wen-Harn Pan
    Jaw-Wen Chen
    [J]. Hypertension Research, 2015, 38 : 155 - 162
  • [8] Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension
    Leu, Hsin-Bang
    Chung, Chia-Min
    Lin, Shing-Jong
    Chiang, Kuang-Mao
    Yang, Hsin-Chou
    Ho, Hung-Yun
    Ting, Chih-Tai
    Lin, Tsung-Hsien
    Sheu, Sheng-Hsiung
    Tsai, Wei-Chuan
    Chen, Jyh-Hong
    Yin, Wei-Hsian
    Chiu, Ting-Yu
    Chen, Chin-Iuan
    Fann, Cathy S. J.
    Chen, Yuan-Tsong
    Pan, Wen-Harn
    Chen, Jaw-Wen
    [J]. HYPERTENSION RESEARCH, 2015, 38 (02) : 155 - 162
  • [9] The role of endothelial dysfunction and inflammation in young-onset hypertension
    Gokaslan, Serkan
    Gokaslan, Cigdem Ozer
    Celik, Sefa
    [J]. ITALIAN JOURNAL OF MEDICINE, 2020, 14 (03) : 151 - 155
  • [10] Markers of lipoprotein lipase and angiotensin I converting enzyme are linked to young-onset hypertension in Taiwan.
    Fann, CS
    Chen, JW
    Jou, YS
    Wu, SY
    Pan, WH
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (04) : 304 - 304