Enhancement of Healing of Long Tubular Bone Defects in Rabbits Using a Mixture of Atelocollagen Gel and Bone Marrow Aspirate Concentrate

被引：6
|
作者：
Park, Ho Youn [1 ]
Shetty, Asode Ananthram [5 ]
Kim, Jang Mook [4 ]
Kim, Young Ju [2 ]
Jang, Jae-Deog [3 ]
Choi, Nam Yong [1 ]
Lee, Jae Ho [1 ]
Kim, Seok Jung [1 ]
机构：
[1] Catholic Univ, Coll Med, Uijeongbu St Marys Hosp, Dept Orthoped Surg, Uijeongbu Si, South Korea
[2] Uijeongbu St Marys Hosp, Dept Nursing Educ & Adm, Uijeongbu Si, South Korea
[3] Catholic Univ, Catholic Inst Cell Therapy, Seoul, South Korea
[4] Dankook Univ, Coll Hlth Sci, Dept Hlth Adm, Cheonan, South Korea
[5] Canterbury Christ Church Univ, Fac Hlth & Social Sci, Chatham, Kent, England
来源：
CELLS TISSUES ORGANS | 2017年 / 203卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Atelocollagen; Osteogenesis; Bone marrow aspirate concentrate; Bone defect; Delayed union; INDUCED CHONDROGENESIS; ARTICULAR-CARTILAGE; FRACTURES; SCAFFOLDS; DIFFERENTIATION; INJECTION; NONUNIONS;
D O I：
10.1159/000455829
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
We evaluated the bone-forming potential of a mixture of atelocollagen and bone marrow aspirate concentrate which was transplanted into bone defects. Radial shaft defects of about 10 mm in size were created in 30 New Zealand white rabbits. Ten rabbits in the control group were not treated further, 10 rabbits in the first experimental group (El) received an atelocollagen injection, and 10 rabbits in the second experimental group (E2) received an injection of a mixture of atelocollagen and bone marrow aspirate concentrate. The groups were compared radiologically at 8 weeks. Osteogenesis in group E2 progressed more rapidly than that in the other groups, and osteogenesis in group El progressed faster than that in the control group. Thus, the administration of a mixture of atelocollagen and bone marrow aspirate concentrate in bone defects was found to enhance bone defect healing. (C) 2017 S. Karger AG, Basel
引用
收藏
页码：339 / 352
页数：14
相关论文
共 50 条
  • [1] Enhancement of bone marrow aspirate concentrate with local self-healing corticotomies
    Shi, Lei
    Tee, Boon Ching
    Emam, Hany
    Prokes, Rachael
    Larsen, Peter
    Sun, Zongyang
    TISSUE & CELL, 2020, 66
  • [2] Bone Marrow Aspirate Concentrate for Bone Healing in Foot and Ankle Surgery
    Harford, Joshua S.
    Dekker, Travis J.
    Adams, Samuel B.
    FOOT AND ANKLE CLINICS, 2016, 21 (04) : 839 - 845
  • [3] Bone Marrow Aspirate Concentrate in Animal Long Bone Healing: An Analysis of Basic Science Evidence
    Gianakos, Arianna
    Ni, Amelia
    Zambrana, Lester
    Kennedy, John G.
    Lane, Joseph M.
    JOURNAL OF ORTHOPAEDIC TRAUMA, 2016, 30 (01) : 1 - 9
  • [4] Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
    Madry, Henning
    Gao, Liang
    Eichler, Hermann
    Orth, Patrick
    Cucchiarini, Magali
    STEM CELLS INTERNATIONAL, 2017, 2017
  • [5] Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
    Xu, Liang
    Urita, Atsushi
    Onodera, Tomohiro
    Hishimura, Ryosuke
    Nonoyama, Takayuki
    Hamasaki, Masanari
    Liang, Dawei
    Homan, Kentaro
    Gong, Jian Ping
    Iwasaki, Norimasa
    AMERICAN JOURNAL OF SPORTS MEDICINE, 2021, 49 (08): : 2199 - 2210
  • [6] Bone Marrow Aspirate Concentrate Combined with in Situ Forming Bioresorbable Gel Enhances Intervertebral Disc Regeneration in Rabbits
    Ukeba, Daisuke
    Yamada, Katsuhisa
    Tsujimoto, Takeru
    Ura, Katsuro
    Nonoyama, Takayuki
    Iwasaki, Norimasa
    Sudo, Hideki
    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2021, 103 (08): : E31
  • [7] A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions
    Mohamed A. Imam
    James Holton
    Lukas Ernstbrunner
    Wojciech Pepke
    Florian Grubhofer
    Ali Narvani
    Martyn Snow
    International Orthopaedics, 2017, 41 : 2213 - 2220
  • [8] A systematic review of the clinical applications and complications of bone marrow aspirate concentrate in management of bone defects and nonunions
    Imam, Mohamed A.
    Holton, James
    Ernstbrunner, Lukas
    Pepke, Wojciech
    Grubhofer, Florian
    Narvani, Ali
    Snow, Martyn
    INTERNATIONAL ORTHOPAEDICS, 2017, 41 (11) : 2213 - 2220
  • [9] Bone marrow aspirate and bone marrow aspirate concentrate: Does the literature support use in long-bone nonunion and provide new insights into mechanism of action?
    Moyal, Andrew J.
    Li, Austin W.
    Adelstein, Jeremy M.
    Moon, Tyler J.
    Napora, Joshua K.
    EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY, 2024, 34 (06): : 2871 - 2880
  • [10] Bone Marrow Aspirate Concentrate for Cartilage Defects of the Knee: From Bench to Bedside Evidence
    Cotter, Eric J.
    Wang, Kevin C.
    Yanke, Adam B.
    Chubinskaya, Susan
    CARTILAGE, 2018, 9 (02) : 161 - 170
12345