Efficient synthesis of trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives from 4-hydroxycoumarin

被引：30
|
作者：
Liao, YX [1 ]
Kuo, PY [1 ]
Yang, DY [1 ]
机构：
[1] Tunghai Univ, Dept Chem, Taichung 407, Taiwan
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 08期
关键词：
4-hydroxycoumarin; fused pyrrole ring;
D O I：
10.1016/S0040-4039(03)00012-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various trisubstituted [1]benzopyrano[4,3-b]pyrrol-4(1H)-one derivatives have been synthesized from 4-hydroxycoumarin with a 30-40% yield over six steps. The key step of the synthesis is a base-promoted intramolecular cyclization of enamines 5, followed by dehydration to generate the fused pyrrole ring. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1599 / 1602
页数：4
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