Haemoglobin wrapped covalently by human serum albumin mutants containing Mn(III) protoporphyrin IX: an O2 complex stable in H2O2 solution

被引：20
|
作者：
Daijima, Y. [1 ]
Komatsu, T. [1 ]
机构：
[1] Chuo Univ, Fac Sci & Engn, Dept Appl Chem, Bunkyo Ku, Tokyo 1128551, Japan
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 94期
关键词：
SUPEROXIDE-DISMUTASE; HYDROGEN-PEROXIDE; BLOOD SUBSTITUTE; BINDING; AUTOXIDATION; CATALASE;
D O I：
10.1039/c4cc06076h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis of a haemoglobin (Hb) wrapped covalently by recombinant human serum albumin mutants [HSA(Y161H)] containing Mn(III) protoporphyrin IX (MnPP), the Hb-[HSA(Y161H)-MnPP](3) cluster, highlighting the formation of its O-2-complex stable even in H2O2 solution.
引用
收藏
页码：14716 / 14719
页数：4
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