In vitro and in vivo activities of Melia azedarach L. aqueous leaf extracts on murine lymphocytes

被引：11
|
作者：
Courreges, MC [1 ]
Benencia, F [1 ]
Coulombie, FC [1 ]
Coto, CE [1 ]
机构：
[1] Univ Buenos Aires, Fac Sci, Virol Lab, RA-1053 Buenos Aires, DF, Argentina
来源：
PHYTOMEDICINE | 1998年 / 5卷 / 01期
关键词：
Melia azedarach L; mouse; leaf extracts; immune system; immunodulation;
D O I：
10.1016/S0944-7113(98)80059-7
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effect of Melia azedarach L. aqueous leaf extracts (Ma) on in vitro lymphocyte proliferation and humoral and cellular immune responses in vivo was studied. Proliferation of spleen and lymph node T cells was impaired when these cells were incubated in the presence of the extract using different mitogens as stimuli. Furthermore, treatment of mice with the extracts not only diminished the production of antibodies but also exerted an inhibition on graft vs host and delayed type hypersensitivity reactions. These results suggest that Ma extracts exert a marked immunomodulatory effect on the mouse immune system.
引用
下载
收藏
页码：47 / 53
页数：7
相关论文
共 50 条
  • [1] Assessment of in vitro Antibacterial and Antifungal Activities of Leaf Extracts of Melia azedarach Linn
    Kathireshan, A. K.
    Priya, T.
    Jasmine, K. Doris
    Gayathri, G.
    Kumar, M. R. Ramesh
    INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 81 (02) : 380 - 384
  • [2] Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands
    Nerome, Kuniaki
    Ito-Kureha, Taku
    Paganini, Tiziana
    Fukuda, Takao
    Igarashi, Yasuhiro
    Ashitomi, Hiroto
    Ikematsu, Shinya
    Yamamoto, Tadashi
    AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 10 (02): : 581 - 594
  • [3] In vitro plant regeneration in Melia azedarach L.
    R. Thakur
    P. S. Rao
    V. A. Bapat
    Plant Cell Reports, 1998, 18 : 127 - 131
  • [4] In vitro plant regeneration in Melia azedarach L.
    Thakur, R
    Rao, PS
    Bapat, VA
    PLANT CELL REPORTS, 1998, 18 (1-2) : 127 - 131
  • [5] Melia azedarach L.
    Yi Ren
    Xumei Wang
    Journal of Pharmaceutical Analysis, 2017, 7 (01) : 4 - 4
  • [6] STUDIES ON EVALUATION OF IN-VITRO ANTFUNGAL ACTIVITIES OF MELIA AZEDARACH L. BARK
    Khatoon, A.
    Mohapatra, A.
    Satapathy, K. B.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2016, 7 (01): : 331 - 335
  • [7] Ecotoxicological evaluation of an aqueous phytoextract of Melia azedarach L.
    Popescu, Vlad Sebastian
    Zhang, Leilei
    Papa, Giulia
    Giuliani, Claudia
    Ribaudo, Giovanni
    Abate, Giulia
    Bulgari, Daniela
    Sweeney, Eileen Mac
    Pucci, Mariachiara
    Bottoni, Martina
    Milani, Fabrizia
    Zizioli, Daniela
    Negri, Ilaria
    Gianoncelli, Alessandra
    Gobbi, Emanuela
    Uberti, Daniela
    Lucini, Luigi
    Memo, Maurizio
    Fico, Gelsomina
    Peron, Gregorio
    Mastinu, Andrea
    SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 950
  • [8] In vitro plant regeneration of Melia azedarach L.:: shoot organogenesis from leaf explants
    Vila, SK
    Gonzalez, AM
    Rey, HY
    Mroginski, LA
    BIOLOGIA PLANTARUM, 2003, 47 (01) : 13 - 19
  • [9] Cytogenetic effects of kernel extracts from Melia azedarach L.
    Özmen, A
    Sümer, E
    CARYOLOGIA, 2004, 57 (03) : 290 - 293
  • [10] Green synthesis of silver nanoparticles using Melia azedarach leaf extract and their antifungal activities: In vitro and in vivo
    Jebril, Siwar
    Ben Jenana, Raoudha Khanfir
    Dridi, Cherif
    MATERIALS CHEMISTRY AND PHYSICS, 2020, 248 (248)
12345