miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5

被引：45

作者：

Zhou, Wenhui ^{[1
,2
,3
,4
,5
]}

Song, Fangfang ^{[4
,5
,6
,7
]}

Wu, Qiuju ^{[4
,5
,6
,7
]}

Liu, Rong ^{[4
,5
]}

Wang, Lulu ^{[2
,3
]}

Liu, Cuicui ^{[2
,3
]}

Peng, You ^{[2
,3
]}

Mao, Shuqin ^{[8
]}

Feng, Jing ^{[1
,2
,3
]}

Chen, Ceshi ^{[4
,5
]}

机构：

[1] Southern Med Univ, Clin Coll 3, Guangzhou, Guangdong, Peoples R China

[2] Southern Med Univ, Affiliated Fengxian Hosp, Dept Lab Med, Shanghai, Peoples R China

[3] Southern Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai, Peoples R China

[4] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan Province, Peoples R China

[5] Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan Province, Peoples R China

[6] Jinzhou Med Univ, Affiliated Fengxian Hosp, Dept Lab Med, Shanghai, Peoples R China

[7] Jinzhou Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai, Peoples R China

[8] Hubei Univ Med, Affiliated Taihe Hosp, Shiyan, Hubei Province, Peoples R China

来源：

PLOS ONE | 2017年 / 12卷 / 04期

关键词：

PANCREATIC DUCTAL ADENOCARCINOMA; TRANSCRIPTION FACTOR; PROTEASOME DEGRADATION; PROLIFERATION; SURVIVAL; MICRORNA-217; CARCINOMA; EXPRESSION; KINASE;

D O I：

10.1371/journal.pone.0176395

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 and KLF5's downstream target gene FGF-BP and Cyclin D1 in TNBC cell lines HCC1806 and HCC1937. Consequently, miR-217 suppresses TNBC cell growth, migration, and invasion. MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression. These results suggest that the miR-217-KLF5 axis might serve as a potential target for treatment of TNBC.

引用

页数：12

共 50 条

[1] Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
Shi, Peiguo
Liu, Wenjing
Tala
Wang, Haixia
Li, Fubing
Zhang, Hailin
Wu, Yingying
Kong, Yanjie
Zhou, Zhongmei
Wang, Chunyan
Chen, Wenlin
Liu, Rong
Chen, Ceshi
CELL DISCOVERY, 2017, 3
[2] Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
Peiguo Shi
Wenjing Liu
Haixia Tala
Fubing Wang
Hailin Li
Yingying Zhang
Yanjie Wu
Zhongmei Kong
Chunyan Zhou
Wenlin Wang
Rong Chen
Ceshi Liu
Cell Discovery, 3
[3] Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
Shi, Peiguo
Zhou, Zhongmei
Liu, Rong
Chen, Ceshi
CANCER RESEARCH, 2017, 77
[4] MiR-630 inhibits cells migration and invasion by targeting SOX4 in triple-negative breast cancer
Liu, Yun-Xiao
Zhao, Li-Ping
Zhang, Ya-Li
Dong, Yan-Yan
Ren, Hua-Yan
Diao, Ke-Xin
Mi, Xiao-Yi
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (09): : 9097 - 9105
[5] MiR-217 Inhibits Proliferation, Migration, and Invasion by Targeting SIRT1 in Osteosarcoma
He, Shaoxuan
Wang, Zhihua
Tang, Hao
Dong, Junjie
Qu, Yongzhou
Lv, Jia
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS, 2019, 34 (04) : 264 - 270
[6] miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5
Wang, Jian
Chu, Yanfeng
Xu, Mei
Zhang, Xiumei
Zhou, Yumei
ONCOLOGY LETTERS, 2019, 17 (02) : 2221 - 2227
[7] miR-613 inhibits cell migration and invasion by downregulating Daam1 in triple-negative breast cancer
Xiong, Huaping
Yan, Ting
Zhang, Weijie
Shi, Fangfang
Jiang, Xuesong
Wang, Xiaohua
Li, Shoushan
Chen, Ying
Chen, Cheng
Zhu, Yichao
CELLULAR SIGNALLING, 2018, 44 : 33 - 42
[8] Ezetimibe inhibits the migration and invasion of triple-negative breast cancer cells by targeting TGFβ2 and EMT
Kong, Lingkai
He, Qinyu
Ma, Ding
Shi, Weiwei
Xin, Qilei
Jiang, Chunping
Wu, Junhua
FEBS OPEN BIO, 2024, 14 (05): : 831 - 842
[9] MiR-940 Inhibited Cell Growth and Migration in Triple-Negative Breast Cancer
Hou, Lingmi
Chen, Maoshan
Yang, Hongwei
Xing, Tianyong
Li, Jingdong
Li, Guangwu
Zhang, Lina
Deng, Shishan
Hu, Jiani
Zhao, Xiaobo
Jiang, Jun
MEDICAL SCIENCE MONITOR, 2016, 22 : 3666 - 3672
[10] Mifepristone suppresses triple-negative breast cancer cell growth and cancer stem cell maintenance via down-regulating KLF5 expression
Liu, R.
Chen, C.
CANCER RESEARCH, 2013, 73

← 1 2 3 4 5 →