A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population

被引：4
|
作者：
Ma, Gaini [1 ,3 ,4 ]
Huang, Xiaoye [1 ,3 ,4 ]
Bi, Yan [1 ,3 ,4 ]
Xu, Fei [1 ,3 ,4 ]
Niu, Weibo [1 ,3 ,4 ]
Ren, Decheng [1 ,3 ,4 ]
Sun, Qianqian [1 ,3 ,4 ]
Guo, Zhenming [1 ,3 ,4 ]
Yuan, Ruixue [1 ,3 ,4 ]
Yuan, Fan [1 ,3 ,4 ]
Wu, Xi [1 ,3 ,4 ]
Yang, Fengping [1 ,3 ,4 ]
Wang, Lu [1 ,3 ,4 ]
Li, Weidong [1 ,3 ,4 ]
He, Lin [1 ,3 ,4 ,5 ]
Yu, Tao [1 ,3 ,4 ]
Li, Xingwang [1 ,3 ,4 ]
Liu, Jie [2 ,3 ,4 ]
He, Guang [1 ,3 ,4 ]
机构：
[1] Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Minist Educ, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Ruijin Hosp, Shanghai Inst Orthopaed & Traumatol, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai, Peoples R China
[5] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
来源：
NEUROPSYCHOBIOLOGY | 2019年 / 78卷 / 03期
关键词：
ABCB1; ABCB6; ABCG1; Polymorphisms; Schizophrenia; MAJOR DEPRESSIVE DISORDER; FUNCTIONAL POLYMORPHISM; SUICIDAL-BEHAVIOR; ASSOCIATION; GENE; METAANALYSIS; VARIANTS; OBESITY; C3435T;
D O I：
10.1159/000496295
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Background: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Mutations in the members of ABC transporters have been associated with psychiatric illnesses. Aims: In this study, we investigated whether 9 SNPs in ABCB1 (rs6946119, rs28401781, rs4148739, and rs3747802), ABCB6 (rs1109866, rs1109867, rs3731885, and rs3755047), and ABCG1 (rs182694) contribute to the risk of SCZ in a Han Chinese population. Methods: We conducted a case-control study in a Han Chinese population, involving 1,034 SCZ patients and 1,034 unrelated healthy controls to genotype 9 SNPs. Results: The analysis demonstrated that rs182694 of ABCG1 was significantly different between SCZ patients and controls as to allele (rs182694: p = 0.0070, chi(2) = 7.27) and genotype frequencies (rs182694: p = 0.0013, chi(2) = 13.35). Conclusions: Our findings support an association between ABCG1 polymorphism and SCZ in a Han Chinese population.
引用
收藏
页码：113 / 117
页数：5
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