FDG-PET predicts treatment efficacy and surgical outcome of pre-operative chemoradiation therapy for resectable and borderline resectable pancreatic cancer

被引：42

作者：

Akita, H. ^{[1
]}

Takahashi, H. ^{[1
]}

Ohigashi, H. ^{[2
]}

Tomokuni, A. ^{[1
]}

Kobayashi, S. ^{[1
]}

Sugimura, K. ^{[1
]}

Miyoshi, N. ^{[1
]}

Moon, J. -H. ^{[1
]}

Yasui, M. ^{[1
]}

Omori, T. ^{[1
]}

Miyata, H. ^{[1
]}

Ohue, M. ^{[1
]}

Fujiwara, Y. ^{[1
]}

Yano, M. ^{[1
]}

Ishikawa, O. ^{[1
]}

Sakon, M. ^{[1
]}

机构：

[1] Osaka Med Ctr Canc & Cardiovasc Dis OMCC, Dept Surg, Osaka, Japan

[2] Saiseikai Senri Hosp, Dept Surg, Suita, Osaka, Japan

来源：

EJSO | 2017年 / 43卷 / 06期

关键词：

Pancreatic cancer; Neoadjuvant; Chemoradiotherapy; FDG-PET; POSITRON-EMISSION-TOMOGRAPHY; GEMCITABINE-BASED CHEMORADIATION; PATHOLOGICAL RESPONSE; ADENOCARCINOMA; SURVIVAL; CHEMORADIOTHERAPY; CHEMOTHERAPY; RECURRENCE; PACLITAXEL; MANAGEMENT;

D O I：

10.1016/j.ejso.2017.03.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The efficacy of neoadjuvant chemoradiotherapy (NACRT) for resectable and borderline resectable pancreatic cancer is important for predicting outcomes after radical surgery, but few clinical indicators predict outcome before resection. This study examined the utility of FDG-PET in predicting the efficacy of NACRT and outcome after radical surgery. Methods: Eighty-three pancreatic cancer patients who underwent FDG-PET before and after NACRT and had positive standard uptake values (SUVs) before NACRT were enrolled in this study. Peri-operative clinical factors, including FDG-PET findings, were examined to predict the efficacy of NACRT and outcome after surgery. Results: Evans grade I, IIA, [03, III, and IV was determined in 11, 31, 27, 11, and 3 patients, respectively. The maximum SUVs after NACRT (post SUV-max) and tumor size were significantly decreased compared to pretreatment values (p < 0.001 and p = 0.007, respectively). The post SUV-max and regression index were significantly related to grade III/IV (p = 0.04 and p < 0.001, respectively), but only the regression index predicted NACRT efficacy (p = 0.002). The AUC of the regression index for the detection of grade III/IV was 0.822, and 13 of 14 grade lII/IV patients were picked up using 50% as the threshold (p < 0.001). Patients with a regression index >50% had a significantly better prognosis after radical resection than patients with <50% (p = 0.032). Regression index as well as pathological lymph node status and resectability status were independent prognostic factors in multivariate analysis (exp 2.086, p = 0.043). Conclusion: The regression index is potentially a good indicator of the efficacy of NACRT and outcome after radical resection for pancreatic cancer. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

引用

页码：1061 / 1067

页数：7