Developing G-quartet oligonucleotides as novel anti-HIV agents: focus on anti-HIV drug design

被引：15

作者：

Jing, NJ ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

来源：

EXPERT OPINION ON INVESTIGATIONAL DRUGS | 2000年 / 9卷 / 08期

关键词：

HIV; human immunodeficiency virus type 1 integrase;

D O I：

10.1517/13543784.9.8.1777

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recently, a new class of oligonucleotides, forming G-quartet structures, has been developed as novel anti-HIV agents. Several critical structure-activity relationships between HIV-1 integrase and G-quartet oligonucleotides have been demonstrated. In addition the mechanism of the inhibition of HIV-I integrase by G-quartet oligonucleotides, such as T30695 and its derivatives, has been explored. This review summarises the preliminary studies of developing G-quartet oligonucleotides as novel anti-HIV agents in several aspects including structure-activity relationship, stability-activity correlation, mechanism of HIV-1 integrase inhibition, substitution of phosphorothioates and targeting HIV-1 integrase in infected cells, which, hopefully, could help for developing a novel, efficient anti-HIV agent.

引用

页码：1777 / 1785

页数：9

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