Response of naive and memory CD8+ T cells to antigen stimulation in vivo

被引：431
|
作者：
Veiga-Fernandes, H [1 ]
Walter, U
Bourgeois, C
McLean, A
Rocha, B
机构：
[1] Inst Necker, INSERM, U345, Paris, France
[2] Inst Necker, INSERM, U373, Paris, France
[3] Inst Anim Hlth, Compton, England
来源：
NATURE IMMUNOLOGY | 2000年 / 1卷 / 01期
关键词：
D O I：
10.1038/76907
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We studied the influence of memory T cell properties on the efficiency of secondary immune responses by comparing the in vivo immune response of the same numbers of T cell receptor (TCR) transgenic (Tg) naive and memory T cells. Compared to naive Tg cells, memory cells divided after a shorter lag time; had an increased division rate; a lower loss rate; and showed move rapid and efficient differentiation to effector functions. We found that initial naive T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector functions simultaneously. These special properties of memory T cells ensure the immediate control of reinfection.
引用
收藏
页码：47 / 53
页数：7
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