Activation of c-Jun N-terminal kinase during ischemia and reperfusion in mouse liver

被引：30
|
作者：
Onishi, I
Tani, T
Hashimoto, T
Shimizu, K
Yagi, M
Yamamoto, K
Yoshioka, K
机构：
[1] Kanazawa Univ, Canc Res Inst, Dept Mol Pathol, Kanazawa, Ishikawa 920, Japan
[2] Kanazawa Univ, Sch Med, Dept Surg 2, Kanazawa, Ishikawa 920, Japan
来源：
FEBS LETTERS | 1997年 / 420卷 / 2-3期
关键词：
ischemia; signal transduction; mitogen-activated protein kinase; c-Jun N-terminal kinase; stress-activated protein kinase;
D O I：
10.1016/S0014-5793(97)01517-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have generated a mouse model for hepatic ischemia in which surgical subcutaneous transposition of the spleen allows hepatic ischemia to be applied without affecting other tissues. Using this mouse model we investigated the relationship between the length of ischemic periods in the liver and subsequent liver function; furthermore, we assayed the activation of c-Jun N-terminal kinase (JNK) during ischemia and reperfusion. Although prior to this study only the activated form of JNK was known to be translocated to the nucleus, we found that JNK translocates to the nucleus during ischemia without activation and is then activated during reperfusion, These results suggest a novel mechanism of JNK activation. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：201 / 204
页数：4
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