Flavonoids as opioid receptor ligands: Identification and preliminary structure-activity relationships

被引：67
|
作者：
Katavic, Peter L.
Lamb, Kenneth
Navarro, Hernan
Prisinzano, Thomas E. [1 ]
机构：
[1] Univ Iowa, Coll Pharm, Div Med & Nat Prod Chem, Iowa City, IA 52242 USA
[2] Res Triangle Inst, Res Triangle Pk, NC 27709 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 08期
关键词：
D O I：
10.1021/np070194x
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Flavonoids have been recognized as the active ingredients of many medicinal plant extracts due to interactions with proteins via phenolic groups and low toxicity. Here, we report the investigation of the flavonoid core as a potential new scaffold for the development of opioid receptor ligands. Biological results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity. Our results also suggest that the actions of Hypericum perforatum may be mediated in part by opioid receptors.
引用
收藏
页码：1278 / 1282
页数：5
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