Ligand-Free, Copper-Catalyzed Aerobic Benzylic sp3 C-H Oxygenation

被引：23

作者：

Tanaka, Hirotaka ^{[1
]}

Oisaki, Kounosuke ^{[1
]}

Kanai, Motomu ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

[2] Japan Sci & Technol Agcy JST, Kanai Life Sci Catalysis Project, ERATO, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan

来源：

SYNLETT | 2017年 / 28卷 / 13期

关键词：

sp(3) C-H oxygenation; copper; oxygen; ligand-free; benzylic oxidation; MOLECULAR-OXYGEN; TERMINAL OXIDANT; EFFICIENT SYNTHESIS; MILD CONDITIONS; AMINO-ACIDS; OXIDATION; BONDS; FUNCTIONALIZATION; SYSTEM; ETHERS;

D O I：

10.1055/s-0036-1588969

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ligand-free and operationally simple copper-catalyzed aerobic benzylic sp(3) C-H oxygenation was developed. The addition of tertbutyl hydroperoxide, either in a catalytic or stoichiometric amount, was key for activating stable C-H bonds under mild conditions to furnish the corresponding ketones or esters in moderate to excellent yield.

引用

页码：1576 / 1580

页数：5

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