Gadolinium-DTPA as X-ray contrast medium in clinical studies

The aim of this study was to investigate the contrast effects of gadolinium (Gd) ill patients undergoing digital subtraction angiography (DSA), intravenous urography (IVU) and CT. 15 patients attending for coeliac axis DSA (n = 5), abdominal CT ( = 5) and IVU (n = 5) were injected with 0.3 mmol kg(-1) Gd-DTPA, the maximum approved dose. For DSA and IVU, images were categorized as being of diagnostic or non-diagnostic quality. For CT, enhancement was measured in Hounsfield Units (HU). On CT, enhancement with Gd was reproducible in all cases; average peak aortic enhancement was 75 HU but duration was short. On IVU, four of five studies yielded positive pyelograms but all nephrograms were relatively poor. On DSA, all five patients had diagnostic arteriograms and four of five indirect portograms were of diagnostic quality. In all 15 cases, enhancement was weaker than that achieved with routine dosage of iodinated agents. In conclusion, Gd chelates may be clinically useful in X-ray studies under certain circumstances on patients with contraindications to iodinated agents. Higher doses than currently approved would be potentially useful.