This article examines the effects of religious involvement on mortality risk among African Americans. The authors use a relatively new and innovative nationally representative data set-the National Health Interview Survey matched to the National Center for Health Statistics' multiple cause of death file-to model this relationship. The results show that, compared with African Americans who attend religious services more than once a week, those who never attend are more than twice as likely to die during the nine-year follow-up period, even net of a large number of confounding and mediating factors. The strong effect of nonattendance on mortality risk is robust, pervasive, and remarkably strong across all subgroups of the population, whereas a moderate level of attendance is associated with higher mortality risk among young adults, men, and Southerners, but not among older adults, women, and non-Southerners. Among African Americans, lack of religious involvement appears to be associated with risk of premature death, whereas frequent religious involvement stands out as a critical, protective factor that contributes to lower mortality and longer life.