The evaluation of non-invasive multi-slice spiral computed tomography-based indices for the diagnosis and prognosis prediction of liver cirrhosis

被引:17
|
作者
Feng, Ling Mei [1 ]
Lei, Shu Juan [1 ]
Zeng, Xin [1 ]
Wang, Pei Qin [1 ]
Chen, Ru Tan [2 ]
Wang, Jian [1 ]
Sheng, Xia [1 ]
Shi, Pei Mei [1 ]
Yuan, Zong Li [1 ]
Xie, Wei Fen [1 ]
机构
[1] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Gastroenterol, 415 Fengyang Rd, Shanghai 200003, Peoples R China
[2] Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Radiol, Shanghai, Peoples R China
关键词
complication; liver cirrhosis; liver function tests; splenic volume; total liver volume; VENOUS-PRESSURE; BODY-WEIGHT; VOLUME; TRANSPLANTATION; ELASTOGRAPHY; FIBROSIS; FORMULA; DISEASE; VARICES; GENDER;
D O I
10.1111/1751-2980.12506
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OBJECTIVE: This study aimed to evaluate easily available computed tomography (CT)-based parameters for assessing the presence and severity of cirrhosis and predicting complications in Chinese patients with cirrhosis. METHODS: CT-based morphological indices were determined in 167 patients with cirrhosis and 244 healthy volunteers. The correlation of morphological indices with Child-Pugh score and cirrhotic complications was analyzed using Spearman's correlation analysis. The area under the receiver operating characteristic curve (AUROC) was used to analyze the diagnostic performance of the indices. Sensitivity and specificity were determined. RESULTS: Patients with cirrhosis had a lower total liver volume (TLV) and a larger total splenic volume (SV) than healthy individuals. There was a significant difference in the portal venous diameter, splenic venous diameter and portal venous cross-sectional area between the two groups. A low TLV/SV ratio was strongly associated with liver cirrhosis; with a cut-off value of 4.27 for the diagnosis of cirrhosis TLV/SV had a sensitivity of 87.7% and a specificity of 84.9%, and AUROC of 0.921. Further analysis showed that TLV/SV was accurate in discriminating between mild and moderate/severe cirrhosis and could be used for predicting complications of cirrhosis. CONCLUSION: The easily available parameters of CT can accurately evaluate the severity of cirrhosis in Chinese patients.
引用
收藏
页码:472 / 479
页数:8
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