Convergent regiodirected assembly of 2,3-disubstituted furans

被引：36
|
作者：
Méndez-Andino, J [1 ]
Paquette, LA [1 ]
机构：
[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 25期
关键词：
D O I：
10.1021/ol000325k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] The conjugate addition of organocopper reagents to alpha,beta -unsaturated enones results in the regiospecific generation of enolate anions, which can be made to undergo the aldol reaction with (tetrahydropyranyloxy)acetaldehyde under zinc chloride catalysis. Treatment of the resulting product with p-toluenesulfonic acid in THF affords the targeted 2,3-disubstituted furan.
引用
收藏
页码：4095 / 4097
页数：3
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