The interaction between microglia and neural stem/precursor cells

被引:38
|
作者
Su, Peng [1 ,2 ]
Zhang, Jianbin [1 ,2 ]
Zhao, Fang [1 ,2 ]
Aschner, Michael [3 ]
Chen, Jingyuan [1 ,2 ]
Luo, Wenjing [1 ,2 ]
机构
[1] Fourth Mil Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, Sch Publ Hlth, Key Lab Hazard Assessment & Control Special Opera, Minist Educ, Xian 710032, Peoples R China
[3] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA
基金
美国国家卫生研究院;
关键词
Microglia; Neurogenesis; Neural stem/precursor cells; Coculture; CAMP-RESPONSE-ELEMENT; PRECURSOR CELLS; STEM-CELLS; SUBVENTRICULAR ZONE; DENTATE GYRUS; BRAIN-INJURY; TRANSCRIPTIONAL ACTIVATION; STEM/PROGENITOR CELLS; ADULT NEUROGENESIS; PROGENITOR CELLS;
D O I
10.1016/j.brainresbull.2014.09.005
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:32 / 38
页数:7
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