Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

被引：20
|
作者：
Zhao, Yaping [3 ]
Sharma, Upendra K. [1 ]
Schroder, Felix [1 ]
Sharma, Nandini [1 ]
Song, Gonghua [3 ]
Van der Eycken, Erik V. [1 ,2 ]
机构：
[1] Univ Leuven KU Leuven, LOMAC, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[2] RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia
[3] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
来源：
RSC ADVANCES | 2017年 / 7卷 / 52期
关键词：
PALLADIUM-CATALYZED C2-ACYLATION; OXIDATIVE ORTHO-ACYLATION; DIRECT ALKYNYLATION; BOND ACYLATION; ALKENYLATION; PYRROLES; 3-ACYLINDOLES; OLEFINATION; ALKALOIDS; ALDEHYDES;
D O I：
10.1039/c7ra06004a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.
引用
收藏
页码：32559 / 32563
页数：5
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