Improvement in the symptoms of smooth muscle dystonia during eculizumab therapy in paroxysmal nocturnal hemoglobinuria

被引：0
|
作者：
Hill, Anita [1 ]
Rother, Russell P. [2 ]
Hillmen, Peter [1 ]
机构：
[1] Leeds Teaching Hosp NHS Trust, Haematol, Leeds LS1 3EX, W Yorkshire, England
[2] Alexion Pharmaceut, Cheshire, CT USA
来源：
HAEMATOLOGICA | 2005年 / 90卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Aberrant smooth muscle dystonia during hemolytic episodes in paroxysmal nocturnal hemoglobinuria (PNH) is implicated in the symptoms of abdominal pain, dysphagia and erectile dysfunction. Here we report two PNH patients treated with the complement inhibitor, eculizumab. Complement inhibition has been sustained for over 2 years and results in resolution of intravascular hemolysis and amelioration of symptoms associated with smooth muscle contractions.
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页码：111 / 113
页数：3
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