Ischemic stroke in neonatal and adult astrocytes

被引：32

作者：

Revuelta, Miren ^{[1
,2
]}

Elicegui, Amaia ^{[1
]}

Moreno-Cugnon, Leire ^{[2
]}

Buehrer, Christoph ^{[1
]}

Matheu, Ander ^{[2
,3
,4
]}

Schmitz, Thomas ^{[1
]}

机构：

[1] Charite Univ Med Ctr, Dept Neonatol, Charitepl 1, D-10117 Berlin, Germany

[2] Biodonostia Hlth Res Inst, Cellular Oncol Grp, Paseo Doctor Begiristain, San Sebastian 20014, Spain

[3] Ikerbasque, Basque Fdn Sci, Maria Diaz Haroko 3, Bilbao 48013, Spain

[4] CIBERfes, Monforte de Lemos 3-5, Madrid 28029, Spain

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2019年 / 183卷

关键词：

Astrocytes; Stroke; Neonatal; Ageing; Hypoxia ischemia; FOCAL CEREBRAL-ISCHEMIA; MICROVASCULAR ENDOTHELIAL-CELLS; IMPROVES FUNCTIONAL RECOVERY; REDUCES BRAIN-DAMAGE; NEURAL STEM-CELLS; NF-KAPPA-B; GROWTH-FACTOR; REACTIVE ASTROCYTES; NEUROTROPHIC FACTOR; DIFFERENTIAL REGULATION;

D O I：

10.1016/j.mad.2019.111147

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The objective of this paper is to review current information regarding astrocytes function after a stroke in neonatal and adult brain. Based on the current literature, there are some molecular differences related to blood brain barrier (BBB) homeostasis disruption, inflammation and reactive oxygen species (ROS) mediated injury between the immature and mature brain after an ischemic event. In particular, astrocytes, the main glial cells in brain, play a different role in neonatal and adult brain after stroke, as time course of glial activation is strongly age dependent. Moreover, the present review provides further insight into the therapeutic approaches of using neonatal and adult astrocytes after stroke. More research will be needed in order to translate them into an effective treatment against stroke, the second main cause of death and disability worldwide.

引用

页数：9

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