P2X7 BLOCKADE REDUCES INTERFERON GAMMA IN A HUMANISED MOUSE MODEL OF GRAFT-VERSUS-HOST DISEASE.

被引：0
|
作者：
Geraghty, Nicholas [1 ,2 ]
Belfiore, Lisa [1 ,2 ]
Mullany, Phillip [1 ,2 ]
Adhikary, Sam R. [1 ,2 ]
Alexander, Stephen [3 ]
Sluyter, Ronald [1 ,2 ]
Watson, Debbie [1 ,2 ]
机构：
[1] Univ Wollongong, Sch Biol Sci, Wollongong, NSW, Australia
[2] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia
[3] Childrens Hosp Westmead, Ctr Kidney Res, Westmead, NSW, Australia
来源：
TRANSPLANTATION | 2015年 / 99卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
131
引用
收藏
页码：S5 / S5
页数：1
相关论文
共 50 条
  • [1] P2X7 RECEPTOR BLOCKADE REDUCES THE CONCENTRATION OF CIRCULATING INTERFERON GAMMA IN A HUMANISED MOUSE MODEL OF GRAFT-VERSUS-HOST DISEASE
    Nicholas, Geraghty
    Lisa, Belfiore
    Phillip, Mullany
    Stephen, Alexander
    Ronald, Sluyter
    Debbie, Watson
    IMMUNOLOGY AND CELL BIOLOGY, 2015, 93 (09): : A21 - A21
  • [2] Increased P2X7 expression in the gastrointestina tract and skin in a humanised mouse model of graft-versus-host disease
    Cuthbertson, Peter
    Adhikary, Sam R.
    Geraghty, Nicholas J.
    Guy, Thomas V.
    Hadjiashrafi, Amirazin
    Fuller, Stephen J.
    Ly, Diane
    Watson, Debbie
    Sluyter, Ronald
    CLINICAL SCIENCE, 2020, 134 (02) : 207 - 223
  • [3] P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model
    Cuthbertson, Peter
    Geraghty, Nicholas J.
    Adhikary, Sam R.
    Casolin, Sienna
    Watson, Debbie
    Sluyter, Ronald
    CLINICAL SCIENCE, 2021, 135 (03) : 495 - 513
  • [4] P2X7 polymorphisms and the role of P2X7 in graft-versus-host disease
    Adhikary, S.
    Geraghty, N.
    Belfiore, L.
    Alexander, S.
    Sluyter, R.
    Watson, D.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 725 - 725
  • [5] The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon- in a humanized mouse model of graft-versus-host disease
    Geraghty, N. J.
    Belfiore, L.
    Ly, D.
    Adhikary, S. R.
    Fuller, S. J.
    Varikatt, W.
    Sanderson-Smith, M. L.
    Sluyter, V.
    Alexander, S. I.
    Sluyter, R.
    Watson, D.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2017, 190 (01): : 79 - 95
  • [6] A Species-Specific Anti-Human P2X7 Monoclonal Antibody Reduces Graft-versus-Host Disease in Humanised Mice
    Elhage, Amal
    Cuthbertson, Peter
    Sligar, Chloe
    Watson, Debbie
    Sluyter, Ronald
    PHARMACEUTICS, 2023, 15 (09)
  • [7] Pro-inflammatory role of the ATP/P2X7 signalling axis in graft-versus-host disease in humanised mice
    Geraghty, N. J.
    Adhikary, S. R.
    Cuthbertson, P.
    Ly, D.
    Guy, T., V
    Belfiore, L.
    Fuller, S. J.
    Alexander, S., I
    Watson, D.
    Sluyter, R.
    PURINERGIC SIGNALLING, 2018, 14 : S57 - S58
  • [8] Role of interferon-gamma in the pathobiology of graft-versus-host disease.
    Murphy, WJ
    Longo, DL
    Blazar, BR
    FASEB JOURNAL, 1998, 12 (04): : A584 - A584
  • [9] Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease
    Geraghty, N. J.
    Watson, D.
    Sluyter, R.
    CELLULAR IMMUNOLOGY, 2019, 336 : 12 - 19
  • [10] Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice
    Adhikary, S. R.
    Geraghty, N. J.
    Cuthbertson, P.
    Sluyter, R.
    Watson, D.
    PURINERGIC SIGNALLING, 2019, 15 (02) : 177 - 192
12345