Role of amyloid precursor protein, amyloid-β and γ-secretase in cholesterol maintenance

被引：15

作者：

Hartmann, Tobias ^{[1
]}

机构：

[1] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany

来源：

NEURODEGENERATIVE DISEASES | 2006年 / 3卷 / 4-5期

关键词：

amyloid precursor protein; amyloid-beta; cholesterol; sphingomyelin; statins; Alzheimer's disease therapy; secretase;

D O I：

10.1159/000095271

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Lipids play an important part as risk factors for Alzheimer's disease. This article summarizes the current understanding of the molecular mechanism by which amyloid-beta (A beta) peptides regulate cholesterol and sphingomyelin metabolism, and how in return cholesterol and sphingomyelin regulate A beta pepticle production. An understanding of the physiological function of amyloid precursor protein processing and A beta function is critical for the development of future therapeutic approaches, e.g. statin treatment. Copyright (c) 2006 S. Karger AG, Basel.

引用

页码：305 / 311

页数：7

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