Inhibition of integrin α5β1 with ATN-161 is profoundly neuroprotective following both transient and permanent middle cerebral artery occlusion in experimental ischaemic stroke

被引：0
|
作者：
Kittani, B. R. [1 ]
Edwards, D. [2 ,3 ]
Reid, E. [1 ]
Macrae, M. I. [1 ]
Holmes, W. M. [4 ]
Bix, G. [2 ,3 ]
McCabe, C. [1 ]
机构：
[1] Univ Glasgow, Wellcome Surg Inst, Glasgow, Lanark, Scotland
[2] Univ Kentucky, Dept Neurol, Lexington, KY 40506 USA
[3] Univ Kentucky, Dept Anat & Neurobiol, Lexington, KY 40506 USA
[4] Univ Glasgow, Glasgow Expt MRI Ctr, Glasgow, Lanark, Scotland
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2017年 / 37卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
PS01-009
引用
收藏
页码：103 / 104
页数：2
相关论文
共 12 条
  • [1] Integrin α5β1 inhibition by ATN-161 reduces neuroinflammation and is neuroprotective in ischemic stroke
    Edwards, Danielle N.
    Salmeron, Kathleen
    Lukins, Douglas E.
    Trout, Amanda L.
    Frasert, Justin F.
    Bix, Gregory J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2020, 40 (08): : 1695 - 1708
  • [2] Inhibition of α5β1 integrin with ATN-161 is neuroprotective and stabilizes the blood-brain barrier after experimental ischemic stroke
    Edwards, D.
    Salmeron, K.
    Fraser, J.
    Bix, G. J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 : 269 - 269
  • [3] Inhibition of [alpha]5[beta]1 Integrin With the Small Peptide ATN-161 Reduces Inflammation, Stabilizes the Blood-Brain Barrier, and is Neuroprotective After Experimental Ischemic Stroke
    Edwards, Danielle
    Salmeron, Katie
    Lukins, Doug
    Fraser, Justin F.
    Bix, Greg J.
    STROKE, 2019, 50
  • [4] Inhibition of α5β1integrin with the clinically validated small peptide, ATN-161 stabilizes cerebral vasculature, reduces inflammation, and decreases blood-brain barrier permeability after experimental ischemic stroke
    Edwards, Danielle
    Salmeron, Katie
    Lukins, Douglas
    Trout, Amanda
    Fraser, Justin
    Bix, Gregory
    FASEB JOURNAL, 2019, 33
  • [5] Neuroprotective effect of interleukin-1 receptor antagonist following permanent middle cerebral artery occlusion is mediated by resident microglia
    Clausen, Bettina Hjelm
    Lambertsen, Kate Lykke
    Babcock, Alicia
    Dagnaes-Hansen, Frederik
    Finsen, Bente
    NEURON GLIA BIOLOGY, 2007, 2 : S159 - S160
  • [6] Neuroprotective Effects of Inhibition of α5β1 Integrin Following Experimental Stroke: A Dual Center Pre-Clinical Study
    Edwards, Danielle
    Kittani, Biav Reber
    Grohs, Gillian
    Macrae, Mhairi
    Fraser, Justin F.
    McCabe, Chris
    Bix, Gregory J.
    STROKE, 2017, 48
  • [7] Inhibition of intercellular adhesion molecule-1 protein expression by antisense oligonucleotides is neuroprotective after transient middle cerebral artery occlusion in rat
    Vemuganti, R
    Dempsey, RJ
    Bowen, KK
    STROKE, 2004, 35 (01) : 179 - 184
  • [8] Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat
    Lennmyr, F
    Ata, KA
    Funa, K
    Olsson, Y
    Terent, A
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (09): : 874 - 882
  • [9] Assessment of poly-arginine peptide R18 following permanent and transient middle cerebral artery occlusion (MCAO) when administered 2 hours after stroke onset
    Milani, D.
    Meloni, B.
    Cross, J.
    Anderton, R.
    Blacker, D.
    Knuckey, N.
    CEREBROVASCULAR DISEASES, 2017, 43
  • [10] Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4 T
    Barber, PA
    Hoyte, L
    Kirk, D
    Foniok, T
    Buchan, A
    Tuor, U
    NEUROSCIENCE LETTERS, 2005, 388 (01) : 54 - 59
12