Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer

被引：28
|
作者：
Tamez, S. [1 ]
Norizoe, C. [1 ]
Ochiai, K. [2 ]
Takahashi, D. [1 ]
Shimojima, A. [1 ]
Tsutsumi, Y. [1 ]
Yanaihara, N. [2 ]
Tanaka, T. [2 ]
Okamoto, A. [2 ]
Urashima, M. [1 ,3 ]
机构：
[1] Jikei Univ, Sch Med, Div Mol Epidemiol, Minato Ku, Tokyo 1058461, Japan
[2] Jikei Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1058461, Japan
[3] Jikei Univ, Sch Med, Dept Pediat, Tokyo 1058461, Japan
来源：
BRITISH JOURNAL OF CANCER | 2009年 / 101卷 / 12期
关键词：
prognosis; single nuclear polymorphisms; SNPs; biomarker; CIRCULATING 25-HYDROXYVITAMIN-D LEVELS; ULTRAVIOLET-B IRRADIANCE; BONE-MINERAL DENSITY; CELL LUNG-CANCER; GENE POLYMORPHISMS; SURVIVAL; RISK; WOMEN;
D O I：
10.1038/sj.bjc.6605414
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Recently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC). METHODS: VDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan-Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour. RESULTS: The FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P = 0.008; adjusted hazard ratio, 0.18; 95% CI 0.05-0.61; P = 0.006). CONCLUSIONS: These results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC. British Journal of Cancer (2009) 101, 1957-1960. doi: 10.1038/sj.bjc.6605414 www.bjcancer.com Published online 10 November 2009 (C) 2009 Cancer Research UK
引用
收藏
页码：1957 / 1960
页数：4
相关论文
共 50 条
  • [1] Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer
    S Tamez
    C Norizoe
    K Ochiai
    D Takahashi
    A Shimojima
    Y Tsutsumi
    N Yanaihara
    T Tanaka
    A Okamoto
    M Urashima
    British Journal of Cancer, 2009, 101 : 1957 - 1960
  • [2] Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer
    Clendenen, Tess V.
    Arslan, Alan A.
    Koenig, Karen L.
    Enquist, Kerstin
    Wirgin, Isaac
    Agren, Asa
    Lukanova, Annekatrin
    Sjodin, Hubert
    Zeleniuch-Jacquotte, Anne
    Shore, Roy E.
    Hallnians, Goran
    Toniolo, Paolo
    Lundin, Eva
    CANCER LETTERS, 2008, 260 (1-2) : 209 - 215
  • [3] Vitamin D Receptor gene polymorphisms and epithelial ovarian cancer risk
    Lurie, Galina
    Wilkens, Lynne R.
    Thompson, Pamela J.
    McDuffie, Katharine E.
    Carney, Michael E.
    Terada, Keith Y.
    Goodman, Marc T.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (12) : 2566 - 2571
  • [4] Polymorphisms in the Vitamin D Receptor and Risk of Ovarian Cancer in Four Studies
    Tworoger, Shelley S.
    Gate, Margaret A.
    Lee, I-Min
    Buring, Julie E.
    Titus-Ernstoff, Linda
    Cramer, Daniel
    Hankinson, Susan E.
    CANCER RESEARCH, 2009, 69 (05) : 1885 - 1891
  • [5] Vitamin D Receptor Gene Polymorphisms, Serum Vitamin D and Poor Predictor Prognosis in IBD Patients
    Zaltman, Cyrla
    Soares-Mota, Marcia
    INFLAMMATORY BOWEL DISEASES, 2017, 23 : S99 - S99
  • [6] Vitamin D Receptor Polymorphisms and Cancer
    Gnagnarella, Patrizia
    Raimondi, Sara
    Aristarco, Valentina
    Johansson, Harriet Ann
    Bellerba, Federica
    Corso, Federica
    Gandini, Sara
    SUNLIGHT, VITAMIN D AND SKIN CANCER, 3RD EDITION, 2020, 1268 : 53 - 114
  • [7] Vitamin D receptor gene polymorphisms in patients with thyroid cancer
    Haghpanah, Vahid
    Ghaffari, Seyed H.
    Rahimpour, Parisa
    Abbasi, Avisa
    Saeedi, Marjan
    Pak, Hale
    Alborzi, Foroogh
    Barzegar, Shaghayegh
    Heshmat, Ramin
    Alimoghadam, Kamran
    Shoushtarizadeh, Peiman
    Tavangar, Seyed Mohammad
    Ghavamazadeh, Ardeshir
    Larijani, Bagher
    GENE THERAPY AND MOLECULAR BIOLOGY, 2007, 11B : 299 - 304
  • [8] Vitamin D receptor polymorphisms are associated with altered prognosis in patients with malignant melanoma
    Hutchinson, PE
    Osborne, JE
    Lear, JT
    Smith, AG
    Bowers, PW
    Morris, PN
    Jones, PW
    York, C
    Strange, RC
    Fryer, AA
    CLINICAL CANCER RESEARCH, 2000, 6 (02) : 498 - 504
  • [9] Expression of Adiponectin Receptor-1 and Prognosis of Epithelial Ovarian Cancer Patients
    Li, Xiahui
    Yu, Zhe
    Fang, Liping
    Liu, Fang
    Jiang, Kui
    MEDICAL SCIENCE MONITOR, 2017, 23 : 1514 - 1521
  • [10] Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis
    Liu, Yanling
    Li, Chenglin
    Chen, Peizhan
    Li, Xiaoguang
    Li, Mian
    Guo, He
    Li, Jingquan
    Chu, Ruiai
    Wang, Hui
    PLOS ONE, 2013, 8 (06):
12345