Vitamin D receptor polymorphisms and prognosis of patients with epithelial ovarian cancer

被引：28
|
作者：
Tamez, S. [1 ]
Norizoe, C. [1 ]
Ochiai, K. [2 ]
Takahashi, D. [1 ]
Shimojima, A. [1 ]
Tsutsumi, Y. [1 ]
Yanaihara, N. [2 ]
Tanaka, T. [2 ]
Okamoto, A. [2 ]
Urashima, M. [1 ,3 ]
机构：
[1] Jikei Univ, Sch Med, Div Mol Epidemiol, Minato Ku, Tokyo 1058461, Japan
[2] Jikei Univ, Sch Med, Dept Obstet & Gynecol, Tokyo 1058461, Japan
[3] Jikei Univ, Sch Med, Dept Pediat, Tokyo 1058461, Japan
来源：
BRITISH JOURNAL OF CANCER | 2009年 / 101卷 / 12期
关键词：
prognosis; single nuclear polymorphisms; SNPs; biomarker; CIRCULATING 25-HYDROXYVITAMIN-D LEVELS; ULTRAVIOLET-B IRRADIANCE; BONE-MINERAL DENSITY; CELL LUNG-CANCER; GENE POLYMORPHISMS; SURVIVAL; RISK; WOMEN;
D O I：
10.1038/sj.bjc.6605414
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Recently, the vitamin D receptor (VDR) polymorphism FokI was shown to be associated with susceptibility to ovarian cancer. We aimed to examine whether VDR FokI polymorphisms influence the survivals of patients with epithelial ovarian cancer (EOC). METHODS: VDR polymorphisms from FokI in 101 patients with EOC were genotyped by sequencing. Overall survival was compared between FokI single nucleotide polymorphism using Kaplan-Meier survival curves with log-rank tests and the Cox proportional hazard model adjusted for ages, stages, histology, and existence of residual tumour. RESULTS: The FokI C/C genotypes were associated with better prognosis compared with the C/T and T/T genotypes (log-rank test: P = 0.008; adjusted hazard ratio, 0.18; 95% CI 0.05-0.61; P = 0.006). CONCLUSIONS: These results suggest that the VDR polymorphisms from the FokI genotype may be associated with improved prognosis of patients with EOC. British Journal of Cancer (2009) 101, 1957-1960. doi: 10.1038/sj.bjc.6605414 www.bjcancer.com Published online 10 November 2009 (C) 2009 Cancer Research UK
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页码：1957 / 1960
页数：4
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