Differences in risk factors for dementia with neurodegenerative traits and for vascular dementia

被引：28
|
作者：
Wehr, H.
Bednarska-Makaruk, M.
Lojkowska, W.
Graban, A.
Hoffman-Zacharska, D.
Kuczynska-Zardzewialy, A.
Mrugala, J.
Rodo, M.
Bochynska, A.
Sulek, A.
Ryglewicz, D.
机构：
[1] Wolski Hosp, Dept Genet, Warsaw, Poland
[2] Wolski Hosp, Dept Neurol 1, Inst Psychiat & Neurol, Warsaw, Poland
[3] Wolski Hosp, Dept Neurogenet, Clin Neurol Epileptol & Sleep Disorders, Inst Mother & Child, Warsaw, Poland
[4] Wolski Hosp, Dept Neurol, Warsaw, Poland
来源：
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2006年 / 22卷 / 01期
关键词：
Alzheimer's disease; mixed dementia; vascular dementia; apolipoprotein E; interleukin 1 beta lipids;
D O I：
10.1159/000092845
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E ( ApoE), low-density-lipoprotein (LDL)-receptor-related protein, alpha(2)-macroglobulin, interleukin (IL)1 beta, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In plasma, antibodies against Chlamydia pneumoniae and lipids were determined. Dementia was classified as probable Alzheimer's disease ( AD), probable dementia of vascular origin (VaD) and mixed dementia ( MD). An association of the disease with ApoE and IL-1 beta polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD. Copyright (C) 2006 S. Karger AG, Basel.
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页数：7
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