Structure and regulation of coronavirus genomes: state-of-the-art and novel insights from SARS-CoV-2 studies

被引:32
|
作者
Manfredonia, Ilaria [1 ]
Incarnato, Danny [1 ]
机构
[1] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst GBB, Dept Mol Genet, Nijenborgh 7, NL-9747 AG Groningen, Netherlands
关键词
MOUSE HEPATITIS-VIRUS; 3' UNTRANSLATED REGION; RESPIRATORY-SYNDROME CORONAVIRUS; PUTATIVE MOLECULAR SWITCH; CIS-ACTING ELEMENT; OPEN READING FRAME; HIV-1 TAR RNA; STEM-LOOP; 5'-UNTRANSLATED-REGION; 3'-UNTRANSLATED REGION;
D O I
10.1042/BST20200670
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Coronaviruses (CoV) are positive-sense single-stranded RNA viruses, harboring the largest viral RNA genomes known to date. Apart from the primary sequence encoding for all the viral proteins needed for the generation of new viral particles, certain regions of CoV genomes are known to fold into stable structures, controlling several aspects of CoV life cycle, from the regulation of the discontinuous transcription of subgenomic mRNAs, to the packaging of the genome into new virions. Here we review the current knowledge on CoV RNA structures, discussing it in light of the most recent discoveries made possible by analyses of the SARS-CoV-2 genome.
引用
收藏
页码:341 / 352
页数:12
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