HNK-1 Carbohydrate, an Attractive Unique Glyco-Epitope

被引：0
|
作者：
Oka, Shogo [1 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Human Hlth Sci, Kyoto 6068507, Japan
来源：
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY | 2019年 / 31卷 / 181期
关键词：
HNK-1; carbohydrate; glucuronyltransferase; synaptic plasticity; AMPA receptor; MYELIN-ASSOCIATED GLYCOPROTEIN; CELL-ADHESION MOLECULES; L2/HNK-1; CARBOHYDRATE; MICE DEFICIENT; GLUCURONOSYLTRANSFERASE; BIOSYNTHESIS; EXPRESSION; ANTIBODY; SULFOTRANSFERASE; CLONING;
D O I：
10.4052/tigg.1905.2SE
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The HNK-1 carbohydrate antigen, which recognized by a monoclonal antibody HNK-1, was originally noticed as a maker of human natural killer (HNK) cells. Subsequent studies revealed that HNK-1 carbohydrate was highly expressed in the nervous system and was commonly expressed on cell adhesion molecules belonging to the immunoglobulin superfamily. Therefore, it was suggested the involvement of HNK-1 carbohydrate in migration of neural crest cells, adhesion of neurons to glial cells, and axon outgrowth. I was interested in this epitope and investigated the biosynthetic enzymes for this epitope. I fortunately received the JSCR Young Investigator Award 1998. In this review, I illustrated a series of our studies including recent findings about the HNK-1 carbohydrate.
引用
收藏
页码：SE12 / SE14
页数：3
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