Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support

被引：33

作者：

Katritzky, AR ^{[1
]}

Xie, LH ^{[1
]}

Zhang, GF ^{[1
]}

Griffith, M ^{[1
]}

Watson, K ^{[1
]}

Kiely, JS ^{[1
]}

机构：

[1] TREGA BIOSCI INC,SAN DIEGO,CA 92121

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 40期

关键词：

D O I：

10.1016/S0040-4039(97)01639-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Resin-immobilized aldimines 5, derived from the condensation of amine-functionalized Rink polystyrene resin with aldehydes, react with Grignard reagents, lithium reagents or LiBH4 to afford a wide variety of primary amines in good to excellent yields upon trifluoroacetic acid cleavage. In this amine synthesis, Rink resin functions both as a solid support and as a NH protecting group. (C) 1997 Elsevier Science Ltd.

引用

页码：7011 / 7014

页数：4

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