Discovery of subtype-selective metabotropic glutamate receptor ligands using functional HTS assays

被引：0
|
作者：
Varney, MA [1 ]
Suto, CM [1 ]
机构：
[1] Merck Res Labs, La Jolla, CA 92037 USA
来源：
DRUG DISCOVERY TODAY | 2000年
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Recent research in the area of metabotropic glutamate receptors suggests that subtype-selective modulators of individual family members could be promising candidates for a variety of nervous system disorders including pain, neurodegeneration and numerous psychiatric diseases. Relatively few subtype-selective metabotropic glutamate receptor ligands have been identified. This article will address how HTS can play an important role in identifying structurally novel ligands as drug leads and research tools.
引用
收藏
页码：20 / 26
页数：7
相关论文
共 50 条
  • [1] Metabotropic glutamate receptors: structure and new subtype-selective ligands
    Pellicciari, R
    Costantino, G
    Marinozzi, M
    Macchiarulo, A
    Camaioni, E
    Natalini, B
    [J]. FARMACO, 2001, 56 (1-2): : 91 - 94
  • [2] Therapeutic potential of non-competitive, subtype-selective metabotropic glutamate receptor ligands
    Mutel, V
    [J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2002, 12 (12) : 1845 - 1852
  • [3] Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model
    Vernon, Anthony C.
    Croucher, Martin J.
    Dexter, David T.
    [J]. NEUROREPORT, 2008, 19 (04) : 475 - 478
  • [4] Attenuation of morphine withdrawal symptoms by subtype-selective metabotropic glutamate receptor antagonists
    Fundytus, ME
    Ritchie, J
    Coderre, TJ
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1997, 120 (06) : 1015 - 1020
  • [5] Subtype-selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 (mGluR1)
    Layton, ME
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (09) : 859 - 867
  • [6] SUBTYPE-SELECTIVE MUSCARINIC LIGANDS FOR RECEPTOR IMAGING
    KIESEWETTER, DO
    LANG, LX
    LEE, JT
    PARK, SG
    PAIK, CH
    HERSCOVITCH, P
    CARSON, RC
    ECKELMAN, WC
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 72 - NUCL
  • [7] SUBTYPE-SELECTIVE MUSCARINIC LIGANDS FOR RECEPTOR IMAGING
    ECKELMAN, WC
    KIESEWETTER, DO
    LANG, L
    LEE, JT
    PARK, SG
    PAIK, CH
    [J]. LIFE SCIENCES, 1995, 56 (11-12) : 1018 - 1018
  • [8] Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives
    Gasparini, F
    Kuhn, R
    Pin, JP
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2002, 2 (01) : 43 - 49
  • [9] [3H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5
    Gasparini, F
    Andres, H
    Flor, PJ
    Heinrich, M
    Inderbitzin, W
    Lingenhöhl, K
    Müller, H
    Munk, VC
    Omilusik, K
    Stierlin, C
    Stoehr, N
    Vranesic, I
    Kuhn, R
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (03) : 407 - 409
  • [10] Molecules subtype-selective NMDA-receptor ligands
    Lloyd, AW
    [J]. DRUG DISCOVERY TODAY, 2000, 5 (02) : 85 - 85
12345