A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A

被引：586
|
作者：
Kawaguchi, Riki
Yu, Jiamei
Honda, Jane
Hu, Jane
Whitelegge, Julian
Ping, Peipei
Wiita, Patrick
Bok, Dean
Sun, Hui
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Pasarow Mass Spectrometry Lab, Semel Inst, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA
来源：
SCIENCE | 2007年 / 315卷 / 5813期
关键词：
D O I：
10.1126/science.1136244
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Vitamin A has diverse biological functions. It is transported in the blood as a complex with retinol binding protein ( RBP), but the molecular mechanism by which vitamin A is absorbed by cells from the vitamin A-RBP complex is not clearly understood. We identified in bovine retinal pigment epithelium cells STRA6, a multitransmembrane domain protein, as a specific membrane receptor for RBP. STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex. It is widely expressed in embryonic development and in adult organ systems. The RBP receptor represents a major physiological mediator of cellular vitamin A uptake.
引用
收藏
页码：820 / 825
页数：6
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