Diastereoselective Construction of Eight-Membered Carbocycles through Palladium-Catalyzed C(sp3)-H Functionalization

被引：11
|
作者：
Wan, Bin [1 ]
Lu, Zhuoer [1 ]
Wu, Zhuo [1 ]
Cheng, Cang [1 ]
Zhang, Yanghui [1 ]
机构：
[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, Shanghai 200092, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 04期
基金：
中国国家自然科学基金;
关键词：
C-H ACTIVATION; PROTON-ABSTRACTION MECHANISM; ARYLATION; BENZOCYCLOBUTENES; CYCLOADDITION; COMPLEXES; CHEMISTRY; CLEAVAGE; PROGRESS; IODIDES;
D O I：
10.1021/acs.orglett.0c04244
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed cross-coupling reaction of 2-alkylphenyl bromides with biphenylene has been developed. The reactions formed eight-membered carbocycles through C(sp(3))-H activation and the formation of two C-C bonds, and the chiral products were obtained with excellent diastereoselectivity. The reaction provides a new strategy for the construction of eight-membered carbocycles, and the products represent a novel type of chiral scaffold.
引用
收藏
页码：1269 / 1274
页数：6
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