Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters

被引：23

作者：

Ohashi, Wakana ^{[1
]}

Hara, Takafumi ^{[2
]}

Takagishi, Teruhisa ^{[2
]}

Hase, Koji ^{[3
]}

Fukada, Toshiyuki ^{[2
,4
,5
]}

机构：

[1] Univ Toyama, Grad Sch Med & Pharmaceut Sci Res, Dept Mol & Med Pharmacol, 2630 Sugitani, Toyama 9300194, Japan

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Mol & Cellular Physiol, 180 Nishihamabouji, Yamashiro, Tokushima 7708055, Japan

[3] Keio Univ, Fac Pharm, Div Biochem, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan

[4] Showa Univ, Sch Dent, Dept Oral Diagnost Sci, Div Pathol,Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan

[5] RIKEN, Ctr Integrat Med Sci, Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300042, Japan

来源：

DIGESTIVE DISEASES AND SCIENCES | 2019年 / 64卷 / 09期

基金：

日本学术振兴会;

关键词：

Zinc; Zinc transporter; Intestinal epithelial cells; Inflammatory bowel disease; Cancer; GENOME-WIDE ASSOCIATION; SQUAMOUS-CELL CARCINOMA; ACRODERMATITIS-ENTEROPATHICA; DIETARY ZINC; STEM-CELLS; PANETH CELLS; MESENCHYMAL TRANSITION; SUSCEPTIBILITY LOCI; MICE LACKING; TUFT CELLS;

D O I：

10.1007/s10620-019-05561-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Zinc is an essential micronutrient for normal organ function, and dysregulation of zinc metabolism has been implicated in a wide range of diseases. Emerging evidence has revealed that zinc transporters play diverse roles in cellular homeostasis and function by regulating zinc trafficking via organelles or the plasma membrane. In the gastrointestinal tract, zinc deficiency leads to diarrhea and dysfunction of intestinal epithelial cells. Studies also showed that zinc transporters are very important in intestinal epithelial homeostasis. In this review, we describe the physiological roles of zinc transporters in intestinal epithelial functions and relevance of zinc transporters in gastrointestinal diseases.

引用

页码：2404 / 2415

页数：12

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