Redox regulation of the ryanodine receptor/calcium release channel

被引：31
|
作者：
Zissimopoulos, S. [1 ]
Lai, F. A. [1 ]
机构：
[1] Cardiff Univ, Sch Med, Dept Cardiol, Wales Heart Res Inst, Cardiff CF14 4XN, S Glam, Wales
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷
基金：
英国惠康基金;
关键词：
calcium signalling; reactive oxygen species; redox regulation; ryanodine receptor; sarcoplasmic reticulum; thiol modification;
D O I：
10.1042/BST0340919
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity. in general, oxidizing conditions favour channel opening, while reducing conditions have the opposite effect. Thiol modification affects the channel sensitivity to its principal effectors, Ca2+, Mg2+ and ATP, and alters RyR protein interactions. Here, we give a brief account of the major findings and prevailing views in the field.
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页码：919 / 921
页数：3
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