Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli

被引：19

作者：

Ogawa, Tadashi

Murakami, Keiko

Mori, Hirotada

Ishii, Nobuyoshi

Tomita, Masaru

Yoshin, Masataka ^{[1
]}

机构：

[1] Aichi Med Univ, Dept Biochem, Sch Med, Aichi 4891195, Japan

[2] Keio Univ, Inst Adv Biosci, Yamagata 9970035, Japan

[3] Nara Inst Sci & Technol, Nara 6300101, Japan

来源：

JOURNAL OF BACTERIOLOGY | 2007年 / 189卷 / 03期

关键词：

D O I：

10.1128/JB.01628-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (K-i of 0.31 mM) and isocitrate lyase uncompetitivelly (K-i' of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt.

引用

页码：1176 / 1178

页数：3

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