Astragaloside IV, the major bioactive component of Astragalus membranaceus (Fisch.) Radix, attenuates airway inflammation by modulating Th2 cytokines and STAT6 in an asthmatic mouse model

被引：0
|
作者：
Chao-Bin, S. [1 ,2 ]
Gu, Y. -N. [2 ,3 ]
Wang, S. [4 ]
Yu, L. [3 ]
机构：
[1] Shanghai TCM Integrated Hosp, Pediat, Shanghai, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shanghai, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Pediat, Shanghai TCM Integrated Hosp, Shanghai, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Pharm, Shanghai, Peoples R China
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2019年 / 49卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P3245
引用
收藏
页码：1943 / 1944
页数：2
相关论文
共 7 条
  • [1] Astragaloside IV, the major bioactive component of Astragalus membranaceus (Fisch.) Radix, attenuates airway inflammation by modulating Th2 cytokines, STAT6 and ROR-γτ transcription factors in an asthmatic mouse model
    Shen, Chao-Bin
    Gu, Yan-Ni
    Wang, Song
    Yu, Lan
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01):
  • [2] 18β-Glycyrrhetinic acid, the major bioactive component of Glycyrrhizae Radix, attenuates airway inflammation by modulating Th2 cytokines, GATA-3, STAT6, and Foxp3 transcription factors in an asthmatic mouse model
    Kim, Seung-Hyung
    Hong, Jung-hee
    Lee, Ji-Eun
    Lee, Young-Cheol
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2017, 52 : 99 - 113
  • [3] Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma
    Kuo, Chieh-Ying
    Huang, Wen-Chung
    Liou, Chian-Jiun
    Chen, Li-Chen
    Shen, Jiann-Jong
    Kuo, Ming-Ling
    MEDIATORS OF INFLAMMATION, 2017, 2017
  • [4] Oral feeding of Lactobacillus bulgaricus N45.10 inhibits the lung inflammation and airway remodeling in murine allergic asthma: Relevance to the Th1/Th2 cytokines and STAT6/T-bet
    Anatriello, E.
    Cunha, M.
    Nogueira, J.
    Carvalho, J. L.
    Sa, A. K.
    Miranda, M.
    Castro-Faria-Neto, H.
    Keller, A. C.
    Aimbire, F.
    CELLULAR IMMUNOLOGY, 2019, 341
  • [5] POTENT AND SELECTIVE ORAL STAT6 DEGRADERS INHIBIT IL-4 AND IL-13 FUNCTIONS IUN HUMAN CELLS AND BLOCK TH2 INFLAMMATION IN VIVO IN A MOUSE MODEL
    Wang, Amy
    Yang, Bin
    Ramanathan, Anand
    Hossain, Alamgir
    Dong, Huijun
    Follows, Bruce
    Browne, Chris
    Harsch, Andreas
    Sawant, Rupa
    Enerson, Bradley E.
    Slavin, Anthony
    Mainolfi, Nello
    GASTROENTEROLOGY, 2024, 166 (05) : S1352 - S1352
  • [6] Potent and Selective Oral STAT6 Degraders Inhibit IL-4 and IL-13 Functions in Human Cells and Block TH2 Inflammation in a House Dust Mite Mouse Model of Asthma
    Wang, A.
    Yang, B.
    Ramanathan, A.
    Hossain, A.
    Dong, H.
    Follows, B.
    Browne, C.
    Harsch, A.
    Sawant, R.
    Enerson, B.
    Slavin, A.
    Mainolfi, N.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [7] Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 pathways in asthmatic mice
    Chen, Bin Lin
    Chen, Yan Qiu
    Ma, Bai Hui
    Yu, Si Fei
    Li, Li Yue
    Zeng, Qing Xiang
    Zhou, Yu Tao
    Wu, Yin Fan
    Liu, Wen Long
    Wan, Jian Bo
    Yang, Yan
    Li, Chun Wei
    CLINICAL AND EXPERIMENTAL ALLERGY, 2018, 48 (11): : 1494 - 1508
1