Arterial thrombosis in a gynecologic oncology patient: Evaluation and management

Background. Arterial thrombosis is an extremely rare complication in gynecologic oncology with only two cases previously reported in the literature. Presentation, evaluation, and treatment varied considerably in all previous reports of arterial thrombosis associated with any malignancy. Case. We report a case of discontinuous arterial thrombosis in the upper extremity of a patient with fallopian tube cancer. Her initial evaluation, done in the acute setting of the thrombosis, revealed multiple thrombophilia abnormalities, including an elevated Factor VIII, and a borderline positive lupus anticoagulant. Follow-up studies over 2 years showed resolution of all coagulation abnormalities, thus indicating no genetic propensity for thrombosis. Conclusion. This case highlights the need for appropriate timing of the initial laboratory studies and follow-up so that patients can be managed appropriately. (C) 2002 Elsevier Science (USA).