Nonsense-mediated mRNA decay at the crossroads of many cellular pathways

被引：52

作者：

Lejeune, Fabrice ^{[1
,2
,3
]}

机构：

[1] Univ Lille, M3T, UMR8161, Mech Tumorigenesis & Target Therapies, F-59000 Lille, France

[2] CNRS, UMR 8161, F-59000 Lille, France

[3] Inst Pasteur, F-59000 Lille, France

来源：

BMB REPORTS | 2017年 / 50卷 / 04期

关键词：

Cellular pathway; Nonsense mutations; Nonsense-mediated mRNA decay (NMD); Quality control mechanism; UPF proteins; EXON-JUNCTION COMPLEX; UNFOLDED PROTEIN RESPONSE; CHILDHOOD-ONSET SCHIZOPHRENIA; PREMATURE TERMINATION CODON; MAMMALIAN-CELLS; 3' UTRS; UPF PROTEINS; INTELLECTUAL DISABILITY; MOLECULAR INSIGHTS; GENE-EXPRESSION;

D O I：

10.5483/BMBRep.2017.50.4.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition.

引用

页码：175 / 185

页数：11

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