Small molecule inhibitors of cyclin-dependent kinase 9 for cancer therapy

被引：19
|
作者：
Alsfouk, Aisha [1 ]
机构：
[1] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh, Saudi Arabia
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2021年 / 36卷 / 01期
关键词：
CDK9; proliferative disorders; kinases;
D O I：
10.1080/14756366.2021.1890726
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclin-dependent kinase 9 (CDK9) plays a vital role in transcription through regulation of short-lived anti-apoptotic genes required for cancer cell survival. Therefore, targeting CDK9 with small molecule inhibitors has emerged as a potential cancer therapy. This article reviews the most recent CDK9 patent literature (2012-2020) related to small molecule inhibitors in cancer along with their selectivity profile and biological results in preclinical studies.
引用
收藏
页码：693 / 706
页数：14
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