Downregulation of miR-140 is Correlated with Poor Prognosis and Progression of Thyroid Cancer

被引：4
|
作者：
Yu, Qianqian [1 ]
Sun, Wenhai [1 ]
Hua, Hui [1 ]
Chi, Yulian [2 ]
Liu, Xiaomin [1 ]
Dong, Anbing [1 ]
Sun, Yinghe [1 ]
Zhang, Jianhua [1 ]
Guan, Ge [3 ]
机构：
[1] Qingdao Univ, Dept Thyroid Surg, Affiliated Hosp, Qingdao 266003, Peoples R China
[2] Qingdao Univ, Med Record Management Ctr, Affiliated Hosp, Qingdao 266003, Peoples R China
[3] Qingdao Univ, Hepat Dis Ctr, Affiliated Hosp, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China
来源：
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2021年 / 21卷 / 04期
关键词：
microRNA-140; thyroid cancer; prognosis; progression; therapeutic target; proliferation; SUPPRESSES CELL-GROWTH; PROLIFERATION; APOPTOSIS; MIGRATION; INVASION; PROMOTES;
D O I：
10.2174/1871530320666200724180742
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The incidence of thyroid cancer is increasing rapidly and there is an urgent need to explore novel therapeutic targets for thyroid cancer. MiR-140 has been reported to affect the progression of various cancers, which makes it possible to play a role in thyroid cancer. This study aimed to investigate the expression and role of miR-140 in thyroid cancer. Methods: The expression of miR-140 was investigated by reverse transcription-quantitative polymerase chain reaction (qRT-PCR) in thyroid cancer tissues and cell lines. The prognostic value of miR-140 in thyroid cancer was evaluated by Kaplan-Meier survival and Cox regression. Moreover, the effects of miR-140 on cell proliferation, migration, and invasion of thyroid cancer were investigated by CCK-8 and Transwell assay. Results: MiR-140 was downregulated in thyroid cancer tissues and cells, which correlated with TNM stage and lymph node metastasis of patients. Patients with low miR-140 expression had a shorter survival time compared with that in patients with high miR-140 expression. Furthermore, miR-140 acts as an independent factor for the prognosis of thyroid cancer. Overexpression of miR-140 inhibited cell proliferation, migration, and invasion of thyroid cancer. Conclusion: MiR-140 can serve as a potential prognostic factor for patients with thyroid cancer and suppress the progression of thyroid cancer, which provides new insight for the therapeutic target for thyroid cancer.
引用
收藏
页码：749 / 755
页数：7
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