Landmark papers on the discovery of methotrexate for the treatment of rheumatoid arthritis and other systemic inflammatory rheumatic diseases: a fascinating story

被引：36

作者：

Malaviya, Anand N. ^{[1
,2
]}

机构：

[1] ISIC Superspecial Hosp, A&R Clin Arthrit & Rheumatism, New Delhi, India

[2] ISIC Superspecial Hosp, Dept Rheumatol, New Delhi, India

来源：

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES | 2016年 / 19卷 / 09期

关键词：

discovery; historical; landmark papers; low-dose methotrexate; rheumatoid arthritis; LOW-DOSE METHOTREXATE; MODIFYING ANTIRHEUMATIC DRUGS; PULSE METHOTREXATE; THERAPEUTIC SUPPRESSION; TISSUE REACTIVITY; DOUBLE-BLIND; RECOMMENDATIONS; PLACEBO; TRIAL; DERMATOMYOSITIS;

D O I：

10.1111/1756-185X.12862

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review highlights the story of how methotrexate (MTX), a drug discovered for the treatment of childhood leukemia, became the mainstay of treatment and the standard-of-care for rheumatoid arthritis (RA) and was also found useful for several additional related rheumatological diseases. As against several synthetic disease-modifying antirheumatic drugs (csDMARDs) for treating RA that were discovered serendipitously, the use of low-dose MTX (LD-MTX) was based on sound reasoning and astute observations made in the 1940s and 1950s. The difference between high-dose MTX (HD-MTX) used in the treatment of childhood leukaemia and other malignancies as against LD-MTX used in rheumatology is emphasized.

引用

页码：844 / 851

页数：8

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