A confetti trail of tumour evolution

被引：6
|
作者：
Janiszewska, Michalina [1 ,2 ,3 ]
Polyak, Kornelia [1 ,2 ,3 ]
机构：
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Med, Boston, MA 02115 USA
[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA
来源：
NATURE CELL BIOLOGY | 2018年 / 20卷 / 06期
关键词：
SKIN; HETEROGENEITY; CANCER;
D O I：
10.1038/s41556-018-0110-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Multiple clones of cancer cells co-exist within a tumour, and yet it is not clear when these subclones arise and how they contribute to tumour progression. A multicolour clonal tracing study now shows that benign skin tumours are mostly monoclonal while the more advanced lesions are composed of multiple intermixed subclones.
引用
收藏
页码：639 / 641
页数：4
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