Research article -: The genome of the sea urchin Strongylocentrotus purpuratus

被引：842

作者：

Sodergren, Erica

Weinstock, George M.

Davidson, Eric H.

Cameron, R. Andrew

Gibbs, Richard A.

Weinstock, George M.

Angerer, Robert C.

Angerer, Lynne M.

Arnone, Maria Ina

Burgess, David R.

Burke, Robert D.

Cameron, R. Andrew

Coffman, James A.

Davidson, Eric H.

Dean, Michael

Elphick, Maurice R.

Ettensohn, Charles A.

Foltz, Kathy R.

Hamdoun, Amro

Hynes, Richard O.

Klein, William H.

Marzluff, William

McClay, David R.

Morris, Robert L.

Mushegian, Arcady

Rast, Jonathan P.

Sodergren, Erica

Smith, L. Courtney

Thorndyke, Michael C.

Vacquier, Victor D.

Weinstock, George M.

Wessel, Gary M.

Wray, Greg

Zhang, Lan

Sodergren, Erica

Weinstock, George M.

Angerer, Robert C.

Angerer, Lynne M.

Cameron, R. Andrew

Davidson, Eric H.

Elsik, Christine G.

Ermolaeva, Olga

Hlavina, Wratko

Hofmann, Gretchen

Kitts, Paul

Landrum, Melissa J.

Mackey, Aaron J.

Maglott, Donna

Panopoulou, Georgia

Poustka, Albert J.

机构：

[1] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

[4] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA

[5] Stn Zool A Dohrn, I-70121 Bari, Italy

[6] Boston Coll, Dept Biol, Chestnut Hill, MA 02467 USA

[7] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3N5, Canada

[8] Mt Desert Isl Biol Lab, Salsbury Cove, ME 04672 USA

[9] NCI, Human Genet Sect, Lab Genom Divers, Frederick, MD 21702 USA

[10] Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England

[11] Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA

[12] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

[13] Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA

[14] Stanford Univ, Hopkins Marine Stn, Pacific Grove, CA 93950 USA

[15] MIT, Howard Hughes Med Inst, Ctr Canc Res, Cambridge, MA 02139 USA

[16] Univ Texas, MD Anderson Canc Ctr, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[17] Univ N Carolina, Dept Mol Biol & Biotechnol, Chapel Hill, NC 27599 USA

[18] Duke Univ, Dept Biol, Durham, NC 27708 USA

[19] Wheaton Coll, Dept Biol, Norton, MA 02766 USA

[20] Stowers Inst Med Res, Kansas City, MO 64110 USA

[21] Univ Kansas, Med Ctr, Dept Microbiol, Kansas City, KS 66160 USA

[22] Univ Toronto, Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada

[23] Univ Toronto, Dept Med Biophys, Toronto, ON M4N 3M5, Canada

[24] Univ Toronto, Dept Immunol, Toronto, ON M4N 3M5, Canada

[25] George Washington Univ, Dept Biol Sci, Washington, DC 20052 USA

[26] Royal Swedish Acad Sci, Kristineberg Marine Res Stn, S-45034 Fiskebackskil, Sweden

[27] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[28] Brown Univ, Dept Mol & Cellular Biol & Biochem, Providence, RI 02912 USA

[29] Duke Univ, Dept Biol, Durham, NC 27708 USA

[30] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA

[31] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA

[32] Natl Ctr Biotechnol Informat, Natl Lib Med, NIH, Bethesda, MD 20894 USA

[33] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA

[34] Natl Ctr Biotechnol Informat, NIH, Bethesda, MD 20892 USA

[35] Univ Penn, Penn Genom Inst, Philadelphia, PA 19104 USA

[36] Max Planck Inst Mol Genet, Evolut & Dev Grp, D-14195 Berlin, Germany

[37] Royal Holloway Univ London, Egham TW20 0EX, Surrey, England

[38] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[39] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[40] Univ S Florida, Dept Biol, Tampa, FL 33618 USA

[41] Univ Paris 06, UMR 7150, Equipe Cycle Cellulaire & Dev, Stn Biol Roscoff, F-29682 Roscoff, France

[42] CNRS, UMR 7150, Stn Biol Roscoff, F-29682 Roscoff, France

[43] Univ Paris 06, UMR7628, F-66650 Banyuls sur Mer, France

[44] Univ N Carolina, Ctr Bioinformat, Chapel Hill, NC 27599 USA

[45] Woods Hole Oceanog Inst, Dept Biol, Woods Hole, MA 02543 USA

[46] Tethys Res LLC, Bangor, ME 04401 USA

[47] Univ Calif Berkeley, Dept Mol Cellular & Dev Biol, Berkeley, CA 94720 USA

[48] Brown Univ, Ctr Computat Mol Biol, Providence, RI 02912 USA

[49] Brown Univ, Dept Comp Sci, Providence, RI 02912 USA

[50] NASA, Ames Res Ctr, Genome Res Facil, Moffett Field, CA 94035 USA

来源：

SCIENCE | 2006年 / 314卷 / 5801期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1126/science.1133609

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

引用

页码：941 / 952

页数：12

共 50 条

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