Update on the management of giant cell arteritis

被引：10

作者：

Roberts, Janet ^{[1
]}

Clifford, Alison ^{[1
]}

机构：

[1] Univ Alberta, Dept Med, Div Rheumatol, 8-130K Clin Sci Bldg, Edmonton, AB T6G 2G3, Canada

来源：

THERAPEUTIC ADVANCES IN CHRONIC DISEASE | 2017年 / 8卷 / 4-5期

关键词：

abatacept; giant cell arteritis; tocilizumab; treatment; VARICELLA-ZOSTER-VIRUS; ISCHEMIC OPTIC NEUROPATHY; PLACEBO-CONTROLLED TRIAL; LARGE-VESSEL INVOLVEMENT; TUMOR-NECROSIS-FACTOR; TEMPORAL ARTERY; DOUBLE-BLIND; TAKAYASU ARTERITIS; TOCILIZUMAB; VZV;

D O I：

10.1177/2040622317700089

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Giant cell arteritis (GCA) is a large vessel vasculitis that may be associated with significant complications such as blindness, stroke, or aortic aneurysm and dissection in a subset of patients. Given the serious side effects associated with prolonged courses of glucocorticoids and frequent relapses experienced when doses are tapered, increased efforts are being dedicated to the discovery of safer and more effective therapies to control this disease. The purpose of this review is to critically evaluate the role of glucocorticoid-sparing agents in the medical management of GCA with a special focus on the most recent evidence regarding the role of biologic agents, including tocilizumab (TCZ), abatacept and ustekinumab, and other novel therapies.

引用

页码：69 / 79

页数：11

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