Square Wave Cathodic Adsorptive Stripping Voltammetric Determination of the Anticancer Drugs Flutamide and Irinotecan in Biological Fluids Using Renewable Pencil Graphite Electrodes

被引：49
|
作者：
Temerk, Yassien M. [1 ]
Ibrahim, Hossieny S. M. [1 ]
Schuhmann, Wolfgang [2 ]
机构：
[1] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt
[2] Ruhr Univ Bochum, CES, Analyt Chem, Univ Str 150, D-44780 Bochum, Germany
来源：
ELECTROANALYSIS | 2016年 / 28卷 / 02期
关键词：
flutamide; irinotecan; voltammetry; pencil graphite electrode; drug analysis; PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; METABOLITE SN-38; ACTIVE METABOLITE; CARBOXYLATE FORMS; HUMAN PLASMA; CANCER DRUG; CPT-11; QUANTIFICATION; PHARMACOKINETICS;
D O I：
10.1002/elan.201500329
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sensitive electrochemical method based on square wave cathodic adsorptive stripping voltammetry (SWCASV) using pencil graphite electrodes (PGE) was developed for the individual and simultaneous determination of the anticancer drugs flutamide (Flu) and irinotecan (Irino) in biological fluids. Calibration curves showed an excellent linear response with limits of detection of 1.68 x 10(-9) and 1.55 x 10(-8) M Irino and Flu, respectively. The statistical evaluation of within-day repeatability (n=5) and day to day precision (n=5) showed satisfactory accuracy and precision. SWCASV using a PGE for individual and simultaneous determination of both drugs in bulk form, human urine and serum samples was demonstrated.
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页码：372 / 379
页数：8
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