From genetics and genomics to drug discovery: yeast rises to the challenge

被引：15
|
作者：
Melese, T
Hieter, P
机构：
[1] Univ Calif San Francisco, Ctr Comprehens Canc, San Francisco, CA 94143 USA
[2] Univ British Columbia, Biotechnol Lab, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2002年 / 23卷 / 12期
关键词：
D O I：
10.1016/S0165-6147(02)02097-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
To identify small-molecule inhibitors of human proteins, a rapid and high-throughput yeast methodology has been developed. Highly sensitive liquid growth assays report the interference of yeast growth caused by the expression of a heterologous protein, and the specificity of the phenotype is validated using known and novel schemas. The development of these high-throughput techniques in yeast validates this organism as an effective paradigm for drug discovery.
引用
收藏
页码：544 / 547
页数：4
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